Concepedia

Lipophilic Efficiency Analysis

Lipophilic Efficiency Analysis is a metric used in medicinal chemistry that quantifies the relationship between a compound's potency and its lipophilicity by normalizing biological activity relative to its octanol-water partition coefficient, thereby distinguishing compounds with optimal balance of potency and lipophilicity.

29

Publications

1.7K

Citations

335

Authors

30

Institutions

Publications per year

2017–2026

6

Variants

Lipe AnalysisLipophilic Efficiency

Parents

Publications

29

Rapid assessment of a novel series of selective CB2 agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis

Thomas Ryckmans, Martin P. Edwards, Val A. Horne et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 269 citations · Full text

, , +17

Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility

Matthew R. Naylor, Andrew M. Ly, Mason J. Handford et al. · Journal of Medicinal Chemistry · 2018 · 197 citations

, , +17

Impact of Lipophilic Efficiency on Compound Quality

Ákos Tarcsay, Kinga Nyíri, György M. Keserű · Journal of Medicinal Chemistry · 2012 · 160 citations

, , +16

Understanding and Improving the Membrane Permeability of VH032-Based PROTACs

Victoria G. Klein, Chad E. Townsend, Andrea Testa et al. · ACS Medicinal Chemistry Letters · 2020 · 140 citations · Full text

, , +16

The thermodynamic basis for the use of lipophilic efficiency (LipE) in enthalpic optimizations

Michael D. Shultz · Bioorganic & Medicinal Chemistry Letters · 2013 · 98 citations · Full text

, , +14

1–5 of 29

Authors

335

  1. MP
    Martin P. Edwards

    Pfizer (United States), United States

    4 publications · 464 citations

    4

    h-index

  2. JP
    Jayvardhan Pandit

    Pfizer (United States), United States

    2 publications · 109 citations

    2

    h-index

  3. MW
    Martin Wythes

    Pfizer (United States), United States

    2 publications · 145 citations

    2

    h-index

  4. CE
    Chad E. Townsend

    University of California, Santa Cruz, United States

    2 publications · 337 citations

    2

    h-index

  5. MR
    Michael R. Collins

    Pfizer (United States), United States

    2 publications · 103 citations

    2

    h-index

1–5 of 335

Institutions

30

  1. Pfizer (United States)

    New York, United States

    9 h-index

    173 publications

    9.2K citations

  2. University of California, Santa Cruz

    Santa Cruz, United States

    2 h-index

    17 publications

    3.2K citations

  3. University of Bonn

    Bonn, Germany

    2 h-index

    8 publications

    144 citations

  4. UCB Pharma (United Kingdom)

    Slough, United Kingdom

    1 h-index

    1 publications

    23 citations

  5. Instituto de Ciências Farmacêuticas

    Goiás, Brazil

    1 h-index

    2 publications

    64 citations

  6. Jamia Millia Islamia

    New Delhi, India

    1 h-index

    3 publications

    69 citations

  7. Janssen (Belgium)

    Beerse, Belgium

    1 h-index

    2 publications

    48 citations

  8. Austrian Competence Centre of Food Safety

    Vienna, Austria

    1 h-index

    1 publications

    30 citations

1–8 of 30

Venues

  1. Journal of Medicinal Chemistry

    11 publications · 807 citations

    11

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    5 publications · 469 citations

    5

    h-index

  3. ACS Medicinal Chemistry Letters

    2 publications · 198 citations

    2

    h-index

  4. 2

    h-index

  5. F1000Research

    2 publications · 36 citations

    2

    h-index

1–5