Chad E. Townsend

Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility

Matthew R. Naylor, Andrew M. Ly, Mason J. Handford et al. · Journal of Medicinal Chemistry · 2018 · 184 citations

Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules

Cameron R. Pye, William M. Hewitt, Joshua Schwochert et al. · Journal of Medicinal Chemistry · 2017 · 151 citations · Full text

Peptide Engineering, Peptide Science, Chemistry +25

Understanding and Improving the Membrane Permeability of VH032-Based PROTACs

Victoria G. Klein, Chad E. Townsend, Andrea Testa et al. · ACS Medicinal Chemistry Letters · 2020 · 129 citations · Full text

Proteinlipid Interaction, Molecular Biology, Membrane Characterization +18

Going Out on a Limb: Delineating The Effects of β-Branching, <i>N</i>-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues

Andrew T. Bockus, Joshua Schwochert, Cameron R. Pye et al. · Journal of Medicinal Chemistry · 2015 · 127 citations

Pharmaceutical Science, Engineering, Peptide Engineering +17

Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry

Akihiro Furukawa, Chad E. Townsend, Joshua Schwochert et al. · Journal of Medicinal Chemistry · 2016 · 94 citations