Martin Wythes

Preparation of enantiomerically pure protected 4-oxo .alpha.-amino acids and 3-aryl .alpha.-amino acids from serine

Richard F. W. Jackson, Neil Wishart, Anthony Wood et al. · The Journal of Organic Chemistry · 1992 · 190 citations

Pharmaceutical Science, Bioorganic Chemistry, Engineering +14

Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1<i>H</i>-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate

Stefano Crosignani, Patrick Bingham, Pauline Bottemanne et al. · Journal of Medicinal Chemistry · 2017 · 134 citations · Full text

Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (<i>R</i>)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2<i>H</i>)-one (PF-06821497)

Pei‐Pei Kung, Patrick Bingham, Alexei Brooun et al. · Journal of Medicinal Chemistry · 2017 · 125 citations · Full text

Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy

Bruno Gomes, Grégory Driessens, Derek W. Bartlett et al. · Molecular Cancer Therapeutics · 2018 · 83 citations · Full text

Design of Selective, ATP-Competitive Inhibitors of Akt

Kevin D. Freeman‐Cook, Christopher Autry, Gary Borzillo et al. · Journal of Medicinal Chemistry · 2010 · 75 citations · Full text

Pharmaceutical Science, Bioorganic Chemistry, Pharmacotherapy +16