Concepedia

Ligand Efficiency Optimization

Ligand Efficiency Optimization is a strategic methodology in lead optimization that refines drug candidates by maximizing their biological activity relative to molecular size or mass, thereby distinguishing itself from other optimization approaches through its focus on efficiency per atom or unit of molecular weight.

197

Publications

13K

Citations

1.2K

Authors

342

Institutions

Publications per year

2017–2026

62

Parents

Children

Publications

197

Phosphorescent iridium(<scp>iii</scp>) complexes: toward high phosphorescence quantum efficiency through ligand control

Youngmin You, Soo Young Park · Dalton Transactions · 2008 · 649 citations

, , +14

Ligand efficiency indices as guideposts for drug discovery

C ABADZAPATERO · Drug Discovery Today · 2005 · 523 citations

, , +14

Optimizing Multivariate Metal–Organic Frameworks for Efficient C<sub>2</sub>H<sub>2</sub>/CO<sub>2</sub> Separation

Weidong Fan, Shuai Yuan, Wenjing Wang et al. · Journal of the American Chemical Society · 2020 · 470 citations

, , +14

A ligand based innovative composite material for selective lead(II) capturing from wastewater

Md. Rabiul Awual, Md. Munjur Hasan · Journal of Molecular Liquids · 2019 · 384 citations

, , +10

Developments in Asymmetric Hydrogenation from an Industrial Perspective

Hideo Shimizu, Izuru Nagasaki, Kazuhiko Matsumura et al. · Accounts of Chemical Research · 2007 · 306 citations

, , +17

1–5 of 197

Authors

1.2K

  1. ÒP
    Òscar Pàmies

    Universitat Rovira i Virgili, Spain

    4 publications · 190 citations

    4

    h-index

  2. MD
    Montserrat Diéguez

    Universitat Rovira i Virgili, Spain

    4 publications · 190 citations

    4

    h-index

  3. PG
    Pher G. Andersson

    Uppsala University, Sweden

    3 publications · 317 citations

    3

    h-index

  4. AH
    André H. M. de Vries

    DSM (Netherlands), Netherlands

    3 publications · 235 citations

    3

    h-index

  5. MS
    Matthew S. Sigman

    University of Utah, United States

    3 publications · 105 citations

    3

    h-index

1–5 of 1.2K

Institutions

342

  1. Chinese Academy of Sciences

    Beijing, China

    9 h-index

    27 publications

    2K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    7 h-index

    25 publications

    1.7K citations

  3. Hong Kong Polytechnic University

    Hong Kong, Hong Kong

    4 h-index

    9 publications

    373 citations

  4. Universitat Rovira i Virgili

    Tarragona, Spain

    4 h-index

    13 publications

    604 citations

  5. Pfizer (United States)

    New York, United States

    3 h-index

    51 publications

    2.8K citations

  6. Inserm

    Paris, France

    3 h-index

    17 publications

    1.1K citations

  7. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    3 h-index

    32 publications

    5K citations

  8. Uppsala University

    Uppsala, Sweden

    3 h-index

    14 publications

    1.6K citations

1–8 of 342

Venues

  1. Journal of Medicinal Chemistry

    23 publications · 1.7K citations

    21

    h-index

  2. The Journal of Organic Chemistry

    JOC · 8 publications · 496 citations

    8

    h-index

  3. Journal of the American Chemical Society

    JACS · 7 publications · 1.3K citations

    7

    h-index

  4. Chemistry - A European Journal

    7 publications · 335 citations

    7

    h-index

  5. Organic Letters

    OL · 6 publications · 516 citations

    6

    h-index

1–5