Concepedia

Developments in Asymmetric Hydrogenation from an Industrial Perspective

Hideo Shimizu, Izuru Nagasaki, Kazuhiko Matsumura, Noboru Sayo, Takao Saito

Accounts of Chemical Research · 2007 · 306 citations · 62 references

DOI

Concepts

Abstract

Examples of developments in asymmetric hydrogenation from various perspectives, in an effort to improve efficiency, are reported. Discussed in this Account are (1) the improved synthesis of BINAP ligands, (2) the design of SEGPHOS ligands for higher enantioselectivity, (3) a new protocol with fewer reaction steps to synthesize beta-aminoesters, and (4) a novel asymmetric hydrogenation mediated by a copper catalyst.

References

62

Asymmetric Catalysis by Architectural and Functional Molecular Engineering: Practical Chemo- and Stereoselective Hydrogenation of Ketones

Ryōji Noyori, Takeshi Ohkuma · Angewandte Chemie International Edition · 2001 · 1.9K citations · Full text

, , +15

Selective Hydrogenation for Fine Chemicals: Recent Trends and New Developments

Hans‐Ulrich Blaser, Christophe Malan, Benoı̂t Pugin et al. · Advanced Synthesis & Catalysis · 2003 · 1.3K citations

, , +16

Synthesis of 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP), an atropisomeric chiral bis(triaryl)phosphine, and its use in the rhodium(I)-catalyzed asymmetric hydrogenation of .alpha.-(acylamino)acrylic acids

Akira Miyashita, Arisa Yasuda, Hidemasa Takaya et al. · Journal of the American Chemical Society · 1980 · 999 citations

, , +10

Asymmetric hydrogenation of .beta.-keto carboxylic esters. A practical, purely chemical access to .beta.-hydroxy esters in high enantiomeric purity

Ryōji Noyori, Takeshi Ohkuma, Masato Kitamura et al. · Journal of the American Chemical Society · 1987 · 755 citations

, , +9

Practical Enantioselective Hydrogenation of Aromatic Ketones

Takeshi Ohkuma, Hirohito Ooka, Shohei Hashiguchi et al. · Journal of the American Chemical Society · 1995 · 719 citations

, , +7