Concepedia

Lead Compound Refinement

Lead Compound Refinement is a methodological process within ligand efficiency optimization that systematically modifies the structural and physicochemical properties of a lead compound to enhance its binding affinity, selectivity, and drug-like characteristics while maintaining optimal ligand efficiency.

15

Publications

664

Citations

79

Authors

14

Institutions

Publications per year

2017–2026

3

Parents

Publications

15

Utility of Complementary Molecular Reactivity and Molecular Recognition (CMR/R) Technology and Polymer-Supported Reagents in the Solution-Phase Synthesis of Heterocyclic Carboxamides

John J. Parlow, Deborah A. Mischke, Scott S. Woodard · The Journal of Organic Chemistry · 1997 · 96 citations

, , +14

Synthesis and crystal structures of two metal phosphonates, M(HO3PC6H5)2(M = Ba, Pb)

Damodara M. Poojary, Baolong Zhang, Aurelio Cabeza et al. · Journal of Materials Chemistry · 1996 · 82 citations

, , +13

Design, Synthesis, and Proposed Active Site Binding Analysis of Monocyclic 2-Azetidinone Inhibitors of Prostate Specific Antigen

Robert M. Adlington, Jack E. Baldwin, Gerald W. Becker et al. · Journal of Medicinal Chemistry · 2001 · 76 citations · Full text

, , +17

Lead Generation - Enhancing the Success of Drug Discovery by Investing in the Hit to Lead Process

Alexander Alanine, Matthias Nettekoven, Edward Roberts et al. · Combinatorial Chemistry & High Throughput Screening · 2003 · 58 citations

, , +16

Practical application of ligand efficiency metrics in lead optimisation

James S. Scott, Michael J. Waring · Bioorganic & Medicinal Chemistry · 2018 · 54 citations · Full text

, , +15

1–5 of 15

Authors

79

  1. AT
    Attilla Ting

    AstraZeneca (United Kingdom), United Kingdom

    1 publications · 15 citations

    1

    h-index

  2. RP
    Raimon Puig de la Bellacasa

    Universitat Ramon Llull, Spain

    1 publications · 14 citations

    1

    h-index

  3. BC
    Beining Chen

    University of Sheffield, United Kingdom

    1 publications · 76 citations

    1

    h-index

  4. SG
    S. Gerhardt

    University of Freiburg, Germany

    1 publications · 15 citations

    1

    h-index

  5. JP
    Jason Pickens

    Takeda (United States), United States

    1 publications · 43 citations

    1

    h-index

1–5 of 79

Institutions

14

  1. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    2 h-index

    5 publications

    114 citations

  2. Jaypee University of Information Technology

    Solan, India

    1 h-index

    2 publications

    28 citations

  3. Roche (Switzerland)

    Basel, Switzerland

    1 h-index

    2 publications

    116 citations

  4. University of Oxford

    Oxford, United Kingdom

    1 h-index

    12 publications

    912 citations

  5. University of Padua

    Padua, Italy

    1 h-index

    4 publications

    180 citations

  6. Takeda (United States)

    Deerfield, United States

    1 h-index

    20 publications

    860 citations

  7. Newcastle University

    Newcastle upon Tyne, United Kingdom

    1 h-index

    1 publications

    54 citations

  8. Institut Químic de Sarrià

    Barcelona, Spain

    1 h-index

    2 publications

    28 citations

1–8 of 14

Venues

  1. Bioorganic & Medicinal Chemistry

    2 publications · 68 citations

    2

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    1 publications · 15 citations

    1

    h-index

  3. Main Group Metal Chemistry

    1 publications · 25 citations

    1

    h-index

  4. Acta Crystallographica

    1 publications · 30 citations

    1

    h-index

  5. Journal of Medicinal Chemistry

    1 publications · 76 citations

    1

    h-index

1–5