Concepedia

Molecular Size Optimization

Molecular Size Optimization is a ligand efficiency optimization metric that normalizes the potency of a compound by its molecular size, typically measured as heavy atom count or molecular weight, to prioritize smaller, more efficient lead compounds in drug discovery.

48

Publications

3.1K

Citations

223

Authors

82

Institutions

Publications per year

2017–2026

10

Parents

Publications

48

Influence of molecular size, polarity and charge on the retention of organic molecules by nanofiltration

Bart Van der Bruggen, Johan Schaep, D. Wilms et al. · Journal of Membrane Science · 1999 · 822 citations

, , +12

Effects of hydrophobicity and molecular size on rejection of aromatic pesticides with nanofiltration membranes

Yoshiaki Kiso · Journal of Membrane Science · 2001 · 309 citations

, , +16

Enhancement of Incident Photon-to-Current Conversion Efficiency for Phthalocyanine-Sensitized Solar Cells by 3D Molecular Structuralization

Shogo Mori, Morio Nagata, Yuki Nakahata et al. · Journal of the American Chemical Society · 2010 · 230 citations

, , +17

The role of molecular size in ligand efficiency

Charles H. Reynolds, Scott D. Bembenek, Brett A. Tounge · Bioorganic & Medicinal Chemistry Letters · 2007 · 165 citations

, , +12

Multiple Interactions of HIV-I Tat Protein with Size-defined Heparin Oligosaccharides

Marco Rusnati, Giovanni Tulipano, Dorothe Spillmann et al. · Journal of Biological Chemistry · 1999 · 120 citations · Full text

, , +13

1–5 of 48

Authors

223

  1. BW
    Bo Wu

    Carolinas Medical Center, United States

    3 publications · 63 citations

    3

    h-index

  2. QL
    Qilong Lu

    Carolinas Medical Center, United States

    3 publications · 63 citations

    3

    h-index

  3. MW
    Mingxing Wang

    Carolinas Medical Center, United States

    3 publications · 63 citations

    3

    h-index

  4. PL
    Peijuan Lu

    Carolinas Medical Center, United States

    3 publications · 63 citations

    3

    h-index

  5. HG
    Henryk Galina

    Rzeszów University of Technology, Poland

    2 publications · 25 citations

    2

    h-index

1–5 of 223

Institutions

82

  1. Carolinas Medical Center

    Charlotte, United States

    3 h-index

    16 publications

    347 citations

  2. Tsinghua University

    Beijing, China

    2 h-index

    7 publications

    226 citations

  3. Dalian University of Technology

    Dalian, China

    2 h-index

    6 publications

    642 citations

  4. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    6 publications

    393 citations

  5. Hiroshima University

    Hiroshima, Japan

    2 h-index

    6 publications

    136 citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    11 publications

    276 citations

  7. Rzeszów University of Technology

    Rzeszów, Poland

    2 h-index

    5 publications

    62 citations

  8. Beijing University of Chemical Technology

    Beijing, China

    1 h-index

    5 publications

    165 citations

1–8 of 82

Venues

  1. Nature Communications

    2 publications · 136 citations

    2

    h-index

  2. Journal of Membrane Science

    2 publications · 1.1K citations

    2

    h-index

  3. Journal of the American Chemical Society

    JACS · 2 publications · 260 citations

    2

    h-index

  4. Bioconjugate Chemistry

    2 publications · 26 citations

    2

    h-index

  5. International Journal of Nanomedicine

    1 publications · 15 citations

    1

    h-index

1–5