Brett A. Tounge

Ligand Binding Efficiency: Trends, Physical Basis, and Implications

Charles H. Reynolds, Brett A. Tounge, Scott D. Bembenek · Journal of Medicinal Chemistry · 2008 · 308 citations

Efficient Ligands, Medicinal Chemistry, Drug Target +14

Frequency Selective Heteronuclear Dipolar Recoupling in Rotating Solids:  Accurate¹³C−¹⁵N Distance Measurements in Uniformly¹³C,¹⁵N-labeled Peptides

Christopher P. Jaroniec, Brett A. Tounge, Judith Herzfeld et al. · Journal of the American Chemical Society · 2001 · 254 citations

Dipolar Couplings, Spin Systems, Spin Textures +19

Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation

Robert H. Scannevin, Richard Alexander, Tara Mezzasalma Haarlander et al. · Journal of Biological Chemistry · 2017 · 171 citations · Full text

The role of molecular size in ligand efficiency

Charles H. Reynolds, Scott D. Bembenek, Brett A. Tounge · Bioorganic & Medicinal Chemistry Letters · 2007 · 164 citations

Engineering, Biochemistry, Ligand Efficiency +4

2-Amino-3,4-dihydroquinazolines as Inhibitors of BACE-1 (β-Site APP Cleaving Enzyme):  Use of Structure Based Design to Convert a Micromolar Hit into a Nanomolar Lead

Ellen W. Baxter, Kelly A. Conway, Ludo Kennis et al. · Journal of Medicinal Chemistry · 2007 · 145 citations · Full text

Combinatorial Chemistry, Drug Target, Chemical Biology +19