Concepedia

Invariant Chain Function

Invariant Chain Function is a molecular regulatory mechanism in antigen presentation that directs the intracellular trafficking and peptide loading of major histocompatibility complex class II molecules by preventing premature binding of endogenous peptides in the endoplasmic reticulum.

306

Publications

19.9K

Citations

1.2K

Authors

373

Institutions

Publications per year

2017–2026

14

Variants

Cd74 Function

Parents

Publications

306

The genome sequence of Atlantic cod reveals a unique immune system

Bastiaan Star, Alexander J. Nederbragt, Sissel Jentoft et al. · Nature · 2011 · 850 citations · Full text

, , +17

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

Paul A. Roche, Peter Cresswell · Nature · 1990 · 488 citations

, , +14

Impaired Invariant Chain Degradation and Antigen Presentation and Diminished Collagen-Induced Arthritis in Cathepsin S Null Mice

T Nakagawa, William H. Brissette, Paul D. Lira et al. · Immunity · 1999 · 412 citations · Full text

, , +17

Developmental Regulation of Invariant Chain Proteolysis Controls MHC Class II Trafficking in Mouse Dendritic Cells

Philippe Pierre, Ira Mellman · Cell · 1998 · 394 citations · Full text

, , +17

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

Janice M. Riberdy, John Newcomb, Michael J. Surman et al. · Nature · 1992 · 381 citations

, , +16

1–5 of 306

Authors

1.2K

  1. OB
    Oddmund Bakke

    University of Oslo, Norway

    21 publications · 1.2K citations

    18

    h-index

  2. HL
    Hidde L. Ploegh

    Harvard University, United States

    12 publications · 598 citations

    12

    h-index

  3. EK
    Elizabeth K. Bikoff

    University of Oxford, United Kingdom

    11 publications · 785 citations

    11

    h-index

  4. NK
    Norbert Koch

    University of Bonn, Germany

    11 publications · 402 citations

    11

    h-index

  5. RB
    Robert Busch

    University of Minnesota, United States

    10 publications · 413 citations

    10

    h-index

1–5 of 1.2K

Institutions

373

  1. Harvard University

    Cambridge, United States

    20 h-index

    112 publications

    6.2K citations

  2. University of Oslo

    Oslo, Norway

    18 h-index

    87 publications

    19K citations

  3. Heidelberg University

    Heidelberg, Germany

    17 h-index

    56 publications

    3.3K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    17 h-index

    68 publications

    7.3K citations

  5. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    15 h-index

    44 publications

    3.9K citations

  6. German Cancer Research Center

    Heidelberg, Germany

    14 h-index

    56 publications

    4.3K citations

  7. National Institutes of Health

    Bethesda, United States

    14 h-index

    42 publications

    2.9K citations

  8. University of Chicago

    Chicago, United States

    13 h-index

    38 publications

    3.6K citations

1–8 of 373

Venues

  1. The Journal of Immunology

    JI · 67 publications · 2.6K citations

    34

    h-index

  2. The Journal of Experimental Medicine

    27 publications · 3.3K citations

    26

    h-index

  3. Journal of Biological Chemistry

    JBC · 24 publications · 1.6K citations

    22

    h-index

  4. European Journal of Immunology

    EJI · 24 publications · 716 citations

    20

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 22 publications · 1.7K citations

    19

    h-index

1–5