Concepedia

Igg Subclass Engineering

IgG Subclass Engineering is a protein engineering strategy that involves the rational modification of immunoglobulin G (IgG) molecules to alter their subclass-specific structural and functional properties, thereby optimizing effector functions, stability, and pharmacokinetics for therapeutic applications.

68

Publications

4.2K

Citations

376

Authors

136

Institutions

Publications per year

2017–2026

14

Parents

Publications

68

Rapid high-yield expression of full-size IgG antibodies in plants coinfected with noncompeting viral vectors

Anatoli Giritch, Sylvestre Marillonnet, Carola Engler et al. · Proceedings of the National Academy of Sciences · 2006 · 421 citations · Full text

, , +14

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

Aran F. Labrijn, Antonio Ortiz Buijsse, Ewald T.J. van den Bremer et al. · Nature Biotechnology · 2009 · 290 citations

, , +10

Impact of Immune Complex Size and Glycosylation on IgG Binding to Human FcγRs

Anja Lux, Xiaojie Yu, Chris Scanlan et al. · The Journal of Immunology · 2013 · 270 citations

, , +11

The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region.

S.M. Canfield, Sherie L. Morrison · The Journal of Experimental Medicine · 1991 · 261 citations · Full text

, , +17

High-throughput, multiplexed IgG subclassing of antigen-specific antibodies from clinical samples

Eric P. Brown, Anna F. Licht, Anne‐Sophie Dugast et al. · Journal of Immunological Methods · 2012 · 252 citations

, , +16

1–5 of 68

Authors

376

  1. SL
    Sherie L. Morrison

    University of California, Los Angeles, United States

    4 publications · 388 citations

    4

    h-index

  2. TE
    Terje E. Michaelsen

    University of Oslo, Norway

    3 publications · 96 citations

    3

    h-index

  3. PL
    P. Lambin

    Institut National de la Transfusion Sanguine, France

    2 publications · 57 citations

    2

    h-index

  4. EL
    Edmundo Lamoyi

    Universidad Nacional Autónoma de México, Mexico

    2 publications · 253 citations

    2

    h-index

  5. AL
    Anja Lux

    Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany

    2 publications · 290 citations

    2

    h-index

1–5 of 376

Institutions

136

  1. BOKU University

    Vienna, Austria

    3 h-index

    19 publications

    918 citations

  2. Harvard University

    Cambridge, United States

    3 h-index

    18 publications

    589 citations

  3. Inserm

    Paris, France

    3 h-index

    7 publications

    355 citations

  4. University of California, Los Angeles

    Los Angeles, United States

    3 h-index

    12 publications

    334 citations

  5. Sorbonne Université

    Paris, France

    3 h-index

    7 publications

    190 citations

  6. Oslo University Hospital

    Oslo, Norway

    2 h-index

    9 publications

    375 citations

  7. Karolinska Institutet

    Stockholm, Sweden

    2 h-index

    3 publications

    57 citations

  8. Friedrich-Alexander-Universität Erlangen-Nürnberg

    Erlangen, Germany

    2 h-index

    4 publications

    580 citations

1–8 of 136

Venues

  1. Journal of Immunological Methods

    8 publications · 681 citations

    8

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 516 citations

    3

    h-index

  3. Molecular Immunology

    3 publications · 79 citations

    3

    h-index

  4. The Journal of Immunology

    JI · 3 publications · 504 citations

    3

    h-index

  5. Journal of Biological Chemistry

    JBC · 2 publications · 136 citations

    2

    h-index

1–5