Ewald T.J. van den Bremer

Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange

Aran F. Labrijn, Joyce Meesters, Bart E.C.G. de Goeij et al. · Proceedings of the National Academy of Sciences · 2013 · 322 citations · Full text

Engineering, Immunology, Molecular Biology +22

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

Aran F. Labrijn, Antonio Ortiz Buijsse, Ewald T.J. van den Bremer et al. · Nature Biotechnology · 2009 · 286 citations

Autoimmune Disease, Therapeutic Igg4 Antibodies, Immunology +12

Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose

Michael J. Gramer, Jackie J. Eckblad, Ruth Donahue et al. · Biotechnology and Bioengineering · 2011 · 181 citations

Bioorganic Chemistry, Glycobiology, Polysaccharide +16

Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen

Guanbo Wang, Rob N. de Jong, Ewald T.J. van den Bremer et al. · Molecular Cell · 2016 · 163 citations · Full text

Immunoglobulin G1, Complement System, Molecular Immunology +14

Controlled Fab-arm exchange for the generation of stable bispecific IgG1

Aran F. Labrijn, Joyce Meesters, Patrick Priem et al. · Nature Protocols · 2014 · 137 citations

Engineering, Biotechnology, Synthetic Biology +3