Guide RNA Design Optimization is a computational or experimental methodology aimed at refining the sequence and structural features of guide RNAs to enhance their specificity and efficiency in targeted genomic interventions while minimizing off-target effects.
22
Publications
3K
Citations
116
Authors
52
Institutions
Publications per year
2017–2026
15
Parents
Publications
22
DeepCRISPR: optimized CRISPR guide RNA design by deep learning
Guohui Chuai, Hanhui Ma, Jifang Yan et al. · Genome biology · 2018 · 598 citations · Full text
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Authors
116
- NE
4
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- AM
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- HW
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- DH
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1–5 of 116
Institutions
52
New York University
New York, United States
4 h-index
20 publications
3.5K citations
New York Genome Center
New York, United States
4 h-index
20 publications
3.5K citations
Broad Institute
Cambridge, United States
2 h-index
3 publications
536 citations
Cornell University
Ithaca, United States
1 h-index
2 publications
576 citations
Ministry of Agriculture
Jakarta, Indonesia
1 h-index
9 publications
558 citations
Inserm
Paris, France
1 h-index
2 publications
170 citations
James Hutton Institute
Dundee, United Kingdom
1 h-index
1 publications
25 citations
University of Massachusetts Chan Medical School
Worcester, United States
1 h-index
1 publications
39 citations
1–8 of 52
Venues
- Nature Biotechnology
3 publications · 820 citations
3
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- Microbial Genomics
MGen · 1 publications · 326 citations
1
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- ACS Synthetic Biology
1 publications · 66 citations
1
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- Antiviral Research
1 publications · 42 citations
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- Frontiers in Biology
1 publications · 39 citations
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