Alejandro Méndez‐Mancilla

Massively parallel Cas13 screens reveal principles for guide RNA design

Hans‐Hermann Wessels, Alejandro Méndez‐Mancilla, Xinyi Guo et al. · Nature Biotechnology · 2020 · 424 citations · Full text

Rna Processing, Functional Genomics, Engineering +10

Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens

Noa Liscovitch‐Brauer, Antonino Montalbano, Jiale Deng et al. · Nature Biotechnology · 2021 · 109 citations · Full text

Chromatin, Chromatin Remodeling, Medicine +11

Prediction of on-target and off-target activity of CRISPR–Cas13d guide RNAs using deep learning

Hans‐Hermann Wessels, Andrew Stirn, Alejandro Méndez‐Mancilla et al. · Nature Biotechnology · 2023 · 103 citations

Crispr–cas13d Guide Rnas, Engineering, Off-target Effect +10

Transcriptome-wide Cas13 guide RNA design for model organisms and viral RNA pathogens

Xinyi Guo, Jahan Rahman, Hans‐Hermann Wessels et al. · Cell Genomics · 2021 · 77 citations · Full text

Efficient combinatorial targeting of RNA transcripts in single cells with Cas13 RNA Perturb-seq

Hans‐Hermann Wessels, Alejandro Méndez‐Mancilla, Yuhan Hao et al. · Nature Methods · 2022 · 75 citations · Full text

Functional Genomics, Rna Transcripts, Single Cell Sequencing +10