Concepedia

Granzyme Pathways

Granzyme Pathways is a biological mechanism that refers to the intracellular signaling cascades initiated by granzymes, serine proteases released by cytotoxic T cells, which induce target cell apoptosis through the cleavage of specific substrates involved in cell survival and homeostasis.

101

Publications

7.1K

Citations

608

Authors

200

Institutions

Publications per year

2017–2026

14

Parents

Publications

101

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

Alison J. Darmon, Donald W. Nicholson, R. Chris Bleackley · Nature · 1995 · 723 citations

, , +14

Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells

William J. Grossman, James Verbsky, Benjamin L. Tollefsen et al. · Blood · 2004 · 521 citations · Full text

, , +15

Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

Jan Paul Medema, Joan de Jong, Lucy T.C. Peltenburg et al. · Proceedings of the National Academy of Sciences · 2001 · 350 citations · Full text

, , +17

Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes

Michael Walch, Farokh Dotiwala, Sachin Mulik et al. · Cell · 2014 · 213 citations · Full text

, , +11

Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.

Sujan Shresta, Debra M. MacIvor, Jonathan W. Heusel et al. · Proceedings of the National Academy of Sciences · 1995 · 208 citations · Full text

, , +13

1–5 of 101

Authors

608

  1. CJ
    Christopher J. Froelich

    Endeavor Health, United States

    7 publications · 532 citations

    7

    h-index

  2. JP
    Jan Paul Medema

    Amsterdam UMC Location University of Amsterdam, Netherlands

    6 publications · 521 citations

    6

    h-index

  3. TV
    Tom van der Poll

    University of Amsterdam, Netherlands

    4 publications · 86 citations

    4

    h-index

  4. JA
    Joseph A. Trapani

    Peter MacCallum Cancer Centre, Australia

    4 publications · 233 citations

    4

    h-index

  5. DM
    Denis Martinvalet

    Harvard University, United States

    4 publications · 254 citations

    4

    h-index

1–5 of 608

Institutions

200

  1. Amsterdam UMC Location University of Amsterdam

    Amsterdam, The Netherlands

    6 h-index

    35 publications

    911 citations

  2. National Institutes of Health

    Bethesda, United States

    6 h-index

    23 publications

    2.4K citations

  3. Inserm

    Paris, France

    5 h-index

    20 publications

    609 citations

  4. Northwestern University

    Evanston, United States

    5 h-index

    17 publications

    2.8K citations

  5. University of British Columbia

    Vancouver, Canada

    5 h-index

    13 publications

    713 citations

  6. University of Alberta

    Edmonton, Canada

    5 h-index

    14 publications

    2.3K citations

  7. Endeavor Health

    Evanston, United States

    4 h-index

    7 publications

    322 citations

  8. University of Amsterdam

    Amsterdam, The Netherlands

    4 h-index

    25 publications

    481 citations

1–8 of 200

Venues

  1. The Journal of Immunology

    JI · 12 publications · 802 citations

    12

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 6 publications · 945 citations

    6

    h-index

  3. PubMed

    Repository · 5 publications · 195 citations

    5

    h-index

  4. Journal of Biological Chemistry

    JBC · 5 publications · 348 citations

    5

    h-index

  5. PLoS ONE

    5 publications · 129 citations

    5

    h-index

1–5