Concepedia

Exonuclease 1

Exonuclease 1 is a nuclease enzyme that belongs to the exonuclease family and is distinguished by its specific role in the 5' to 3' excision of nucleotides during DNA mismatch repair, thereby enabling the correction of replication errors.

460

Publications

38K

Citations

2.2K

Authors

662

Institutions

Publications per year

2017–2026

80

Variants

Exo1

Parents

Publications

460

Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

Yanick J. Crow, Bruce E. Hayward, Rekha Parmar et al. · Nature Genetics · 2006 · 892 citations

, , +7

BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair

Amitabh V. Nimonkar, Jochen Genschel, Eri Kinoshita et al. · Genes & Development · 2011 · 736 citations · Full text

, , +16

Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus

Min Ae Lee‐Kirsch, Maolian Gong, Dipanjan Chowdhury et al. · Nature Genetics · 2007 · 725 citations

, , +10

DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells

Hiro Sato, Atsuko Niimi, Takaaki Yasuhara et al. · Nature Communications · 2017 · 701 citations · Full text

, , +17

Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease

Yun‐Gui Yang, Tomas Lindahl, Deborah E. Barnes · Cell · 2007 · 581 citations · Full text

, , +16

1–5 of 460

Authors

2.2K

  1. BS
    Binghui Shen

    City Of Hope National Medical Center, United States

    12 publications · 867 citations

    12

    h-index

  2. FW
    Fred W. Perrino

    Wake Forest University, United States

    10 publications · 1.7K citations

    10

    h-index

  3. DM
    David M. Wilson

    National Institute on Aging, United States

    9 publications · 689 citations

    9

    h-index

  4. RD
    Richard D. Kolodner

    University of California San Diego, United States

    8 publications · 1.4K citations

    8

    h-index

  5. TH
    Thomas Hollis

    Wake Forest University, United States

    7 publications · 1.2K citations

    7

    h-index

1–5 of 2.2K

Institutions

662

  1. Centre National de la Recherche Scientifique

    Paris, France

    17 h-index

    80 publications

    6.1K citations

  2. National Institutes of Health

    Bethesda, United States

    17 h-index

    53 publications

    4.5K citations

  3. Harvard University

    Cambridge, United States

    16 h-index

    44 publications

    13K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    16 h-index

    49 publications

    6.3K citations

  5. National Institute on Aging

    Baltimore, United States

    14 h-index

    32 publications

    1.7K citations

  6. University of Oxford

    Oxford, United Kingdom

    14 h-index

    52 publications

    5.9K citations

  7. Yale University

    New Haven, United States

    12 h-index

    37 publications

    2.2K citations

  8. University of Zurich

    Zurich, Switzerland

    12 h-index

    44 publications

    3K citations

1–8 of 662

Venues

  1. Journal of Biological Chemistry

    JBC · 65 publications · 5.9K citations

    45

    h-index

  2. Nucleic Acids Research

    54 publications · 3.7K citations

    32

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 21 publications · 2.4K citations

    20

    h-index

  4. Molecular and Cellular Biology

    MCB · 19 publications · 2.3K citations

    19

    h-index

  5. DNA repair

    12 publications · 509 citations

    12

    h-index

1–5