Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus

Recognition of Cytosolic DNA Activates an IRF3-Dependent Innate Immune Response

Daniel B. Stetson, Ruslan Medzhitov · Immunity · 2006 · 995 citations · Full text

Inflammation, Host Response, Innate Immune System +8

Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

Yanick J. Crow, Bruce E. Hayward, Rekha Parmar et al. · Nature Genetics · 2006 · 876 citations

Ags1 Locus, Mendelian Disorder, Genetic Disorder +11

Features of systemic lupus erythematosus in Dnase1-deficient mice

Markus Napirei, Holger Karsunky, Branko Zevnik et al. · Nature Genetics · 2000 · 776 citations

Autoimmune Disease, Systemic Lupus Erythematosus, Systemic Lupus Erythematosus Treatment +10

Mutation of DNASE1 in people with systemic lupus erythematosus

Koji Yasutomo, Takahiko Horiuchi, Shoji Kagami et al. · Nature Genetics · 2001 · 583 citations

Genome Instability, Autoimmune Disease, Systemic Lupus Erythematosus +7

Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages

Kohki Kawane, Mayumi Ohtani, Keiko Miwa et al. · Nature · 2006 · 453 citations

Inflammation, Rheumatology, Mammalian Dna +13