Concepedia

Enzyme Selectivity Design

Enzyme Selectivity Design is a computational enzyme design methodology that specifically optimizes an enzyme's ability to discriminate between competing substrates or reaction pathways, thereby enabling precise control over catalytic outcome through targeted modulation of active site architecture and molecular recognition properties.

22

Publications

1.1K

Citations

139

Authors

46

Institutions

Publications per year

2017–2026

5

Parents

Publications

22

GRID/CPCA:  A New Computational Tool To Design Selective Ligands

Mika A. Kastenholz, Manuel Pastor, Gabriele Cruciani et al. · Journal of Medicinal Chemistry · 2000 · 184 citations · Full text

, , +16

Aloisines, a New Family of CDK/GSK-3 Inhibitors. SAR Study, Crystal Structure in Complex with CDK2, Enzyme Selectivity, and Cellular Effects

Yvette Mettey, Marie Gompel, Virginie Thomas et al. · Journal of Medicinal Chemistry · 2002 · 146 citations · Full text

, , +17

Novel 3,5-Bis(bromohydroxybenzylidene)piperidin-4-ones as Coactivator-Associated Arginine Methyltransferase 1 Inhibitors: Enzyme Selectivity and Cellular Activity

Donghang Cheng, Sérgio Valente, Sabrina Castellano et al. · Journal of Medicinal Chemistry · 2011 · 83 citations · Full text

, , +14

Structure-Based Design of a General Class of Mechanism-Based Inhibitors of the Serine Proteinases Employing a Novel Amino Acid-Derived Heterocyclic Scaffold

William C. Groutas, Rongze Kuang, R. Venkataraman et al. · Biochemistry · 1997 · 79 citations

, , +16

Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines

Thanh Lam, M.T. Hilgers, Mark L. Cunningham et al. · Journal of Medicinal Chemistry · 2014 · 71 citations · Full text

, , +17

1–5 of 22

Authors

139

  1. YY
    Yongliang Yang

    Dalian University of Technology, China

    1 publications · 14 citations

    1

    h-index

  2. JQ
    John Quin

    Pfizer (United States), United States

    1 publications · 62 citations

    1

    h-index

  3. AT
    Andrew T. Papoulis

    Indiana University School of Medicine

    1 publications · 47 citations

    1

    h-index

  4. AR
    A. Rosowsky

    European Organization for Nuclear Research, Switzerland

    1 publications · 47 citations

    1

    h-index

  5. LM
    Laurent Meijer

    Station Biologique de Roscoff, France

    1 publications · 146 citations

    1

    h-index

1–5 of 139

Institutions

46

  1. Harvard University

    Cambridge, United States

    3 h-index

    12 publications

    375 citations

  2. Chengdu University

    Chengdu, China

    1 h-index

    1 publications

    23 citations

  3. Kansas State University

    Manhattan, United States

    1 h-index

    6 publications

    474 citations

  4. Shahid Beheshti University of Medical Sciences

    Tehran, Iran

    1 h-index

    3 publications

    36 citations

  5. Kobe Gakuin University

    Kobe, Japan

    1 h-index

    2 publications

    38 citations

  6. University of Oxford

    Oxford, United Kingdom

    1 h-index

    8 publications

    296 citations

  7. University of Hawaiʻi at Mānoa

    Honolulu, United States

    1 h-index

    1 publications

    23 citations

  8. Sapienza University of Rome

    Rome, Italy

    1 h-index

    4 publications

    332 citations

1–8 of 46

Venues

  1. Journal of Medicinal Chemistry

    9 publications · 686 citations

    9

    h-index

  2. Angewandte Chemie International Edition

    2 publications · 60 citations

    2

    h-index

  3. PubMed

    Repository · 1 publications · 12 citations

    1

    h-index

  4. Journal of Agricultural and Food Chemistry

    1 publications · 23 citations

    1

    h-index

  5. ChemBioChem

    1 publications · 22 citations

    1

    h-index

1–5