Concepedia

Enzyme Saturation

Enzyme Saturation is a pharmacokinetic phenomenon characterized by the maximal binding of a drug to metabolizing enzymes, wherein the rate of metabolism reaches a plateau due to the limited availability of free enzyme active sites, distinguishing it from linear metabolic processes by exhibiting capacity-limited kinetics.

157

Publications

10.3K

Citations

431

Authors

158

Institutions

Publications per year

2017–2026

5

Variants

Capacity-limited Kinetics

Parents

Children

Publications

157

A simple and sensitive saturation assay method for the measurement of adenosine 3′:5′-cyclic monophosphate

B. L. Brown, J. D. M. Albano, Roger Ekins et al. · Biochemical Journal · 1971 · 1.5K citations · Full text

, , +7

A Comparison of Estimates of Michaelis-Menten Kinetic Constants from Various Linear Transformations

John E. Dowd, Douglas S. Riggs · Journal of Biological Chemistry · 1965 · 1.1K citations · Full text

, , +16

Expanding the Range of Substrate Acceptance of Enzymes: Combinatorial Active‐Site Saturation Test

Manfred T. Reetz, Marco Bocola, José Daniel Carballeira et al. · Angewandte Chemie International Edition · 2005 · 504 citations

, , +14

Saturation assay for cyclic AMP using endogenous binding protein.

Brown Bl, Ekins Rp, Albano Jd · PubMed · 1972 · 323 citations

, , +13

Global characterization of in vivo enzyme catalytic rates and their correspondence to in vitro <i>k</i> <sub>cat</sub> measurements

Dan Davidi, Wolfram Liebermeister, Arren Bar‐Even et al. · Proceedings of the National Academy of Sciences · 2016 · 288 citations · Full text

, , +17

1–5 of 157

Authors

431

  1. GW
    G. Wesley Hatfield

    University of California, Irvine, United States

    3 publications · 153 citations

    3

    h-index

  2. HE
    H. E. Umbarger

    Purdue University West Lafayette, United States

    3 publications · 153 citations

    3

    h-index

  3. AA
    Abdulla A.‐B. Badawy

    Whitchurch Hospital, United Kingdom

    3 publications · 86 citations

    3

    h-index

  4. GP
    Gerd Puchwein

    University of Graz, Austria

    2 publications · 88 citations

    2

    h-index

  5. PJ
    Patricio J. Garrahan

    Instituto de Química y Fisicoquímica Biológicas, Argentina

    2 publications · 40 citations

    2

    h-index

1–5 of 431

Institutions

158

  1. National Institutes of Health

    Bethesda, United States

    5 h-index

    15 publications

    906 citations

  2. Columbia University

    New York, United States

    4 h-index

    12 publications

    860 citations

  3. University of Oxford

    Oxford, United Kingdom

    4 h-index

    9 publications

    824 citations

  4. Weizmann Institute of Science

    Rehovot, Israel

    3 h-index

    8 publications

    1.4K citations

  5. Universidad de Buenos Aires

    Buenos Aires, Argentina

    3 h-index

    9 publications

    206 citations

  6. Whitchurch Hospital

    Cardiff, United Kingdom

    3 h-index

    7 publications

    197 citations

  7. Purdue University West Lafayette

    West Lafayette, United States

    3 h-index

    7 publications

    341 citations

  8. Rutgers, The State University of New Jersey

    New Brunswick, United States

    2 h-index

    3 publications

    51 citations

1–8 of 158

Venues

  1. Journal of Biological Chemistry

    JBC · 34 publications · 2.8K citations

    24

    h-index

  2. European Journal of Biochemistry

    EJB · 11 publications · 307 citations

    11

    h-index

  3. Biochemistry

    11 publications · 585 citations

    11

    h-index

  4. Biochemical Journal

    BJ · 10 publications · 267 citations

    10

    h-index

  5. PubMed

    Repository · 5 publications · 434 citations

    5

    h-index

1–5