Concepedia

Dose-dependent Nonlinearity

Dose-Dependent Nonlinearity is a kinetic phenomenon in enzyme catalysis wherein the relationship between substrate concentration and reaction rate deviates from linearity in a manner that depends explicitly on the dose of substrate, reflecting saturable enzyme binding kinetics distinct from simple linear proportionality.

20

Publications

658

Citations

127

Authors

54

Institutions

Publications per year

2017–2026

5

Parents

Publications

20

“Dose-dependent” Impact of Recurrent Cardiac Events on Mortality in Patients with Heart Failure

Douglas S. Lee, Peter C. Austin, Thérèse A. Stukel et al. · The American Journal of Medicine · 2008 · 106 citations

, , +15

Mechanism for the Nonlinear Pharmacokinetics of Erythropoietin in Rats

Motohiro Kato, Hiroshi Kamiyama, Kenji Kumaki et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 71 citations

, , +11

RNAs competing for microRNAs mutually influence their fluctuations in a highly non-linear microRNA-dependent manner in single cells

Carla Bosia, Francesco Sgrò, Laura Conti et al. · Genome biology · 2017 · 52 citations · Full text

, , +16

Determination of Urine 3-HPMA, a Stable Acrolein Metabolite in a Rat Model of Spinal Cord Injury

Lingxing Zheng, Jonghyuck Park, Michael Walls et al. · Journal of Neurotrauma · 2013 · 50 citations · Full text

, , +5

Nonlinear Pharmacokinetics of Oral Quinidine and Verapamil in Healthy Subjects: A Clinical Microdosing Study

Kazuya Maeda, Junichi Takano, Yasumasa Ikeda et al. · Clinical Pharmacology & Therapeutics · 2011 · 50 citations

, , +13

1–5 of 20

Authors

127

  1. YS
    Yuichi Sugiyama

    The University of Tokyo, Japan

    2 publications · 121 citations

    2

    h-index

  2. CE
    Christine E. Brown

    City Of Hope National Medical Center, United States

    1 publications · 23 citations

    1

    h-index

  3. SW
    Shyh‐Yuh Wei

    National Cheng Kung University Hospital, Taiwan

    1 publications · 21 citations

    1

    h-index

  4. MA
    Michael A. Nitsche

    University of Göttingen, Germany

    1 publications · 21 citations

    1

    h-index

  5. LH
    Larry Hammond

    Dow Chemical (United States), United States

    1 publications · 34 citations

    1

    h-index

1–5 of 127

Institutions

54

  1. Institute for Clinical Evaluative Sciences

    Toronto, Canada

    1 h-index

    6 publications

    636 citations

  2. Sunnybrook Health Science Centre

    Toronto, Canada

    1 h-index

    1 publications

    106 citations

  3. Sangji University

    Wŏnju, South Korea

    1 h-index

    1 publications

    23 citations

  4. Exponent (United States)

    Menlo Park, United States

    1 h-index

    2 publications

    68 citations

  5. University of Wisconsin–Madison

    Madison, United States

    1 h-index

    6 publications

    78 citations

  6. Konkuk University

    Seoul, South Korea

    1 h-index

    6 publications

    138 citations

  7. TU Dortmund University

    Dortmund, Germany

    1 h-index

    4 publications

    84 citations

  8. Kitasato University Hospital

    Sagamihara, Japan

    1 h-index

    3 publications

    150 citations

1–8 of 54

Venues

  1. Drug Metabolism and Disposition

    2 publications · 34 citations

    2

    h-index

  2. Cerebral Cortex

    1 publications · 21 citations

    1

    h-index

  3. Journal of Interferon & Cytokine Research

    1 publications · 23 citations

    1

    h-index

  4. Human Gene Therapy

    1 publications · 46 citations

    1

    h-index

  5. Medical Physics

    1 publications · 13 citations

    1

    h-index

1–5