Concepedia

Competitive Saturation

Competitive Saturation is a theoretical construct in enzyme kinetics that specifically describes the condition under which an enzyme's active sites are fully occupied by substrate molecules in the presence of a competitive inhibitor, thereby reaching maximal reaction velocity only at indefinitely high substrate concentrations.

81

Publications

4K

Citations

280

Authors

103

Institutions

Publications per year

2017–2026

13

Parents

Publications

81

Computational Fragment-Based Binding Site Identification by Ligand Competitive Saturation

Olgun Guvench, Alexander D. MacKerell · PLoS Computational Biology · 2009 · 271 citations · Full text

, , +17

Affinity and intrinsic activity in the theory of competitive inhibition. I. Problems and theory.

Ariëns Ej · PubMed · 1954 · 218 citations

, , +6

Studies on alkaline phosphatase. Inhibition by phosphate derivatives and the substrate specificity

H N Fernley, P. G. Walker · Biochemical Journal · 1967 · 177 citations · Full text

, , +12

Reproducing Crystal Binding Modes of Ligand Functional Groups Using Site-Identification by Ligand Competitive Saturation (SILCS) Simulations

E. Prabhu Raman, Wenbo Yu, Olgun Guvench et al. · Journal of Chemical Information and Modeling · 2011 · 141 citations

, , +17

Inclusion of Multiple Fragment Types in the Site Identification by Ligand Competitive Saturation (SILCS) Approach

E. Prabhu Raman, Wenbo Yu, Sirish Kaushik Lakkaraju et al. · Journal of Chemical Information and Modeling · 2013 · 136 citations · Full text

, , +17

1–5 of 81

Authors

280

  1. AD
    Alexander D. MacKerell

    University of Maryland, Baltimore, United States

    18 publications · 1.2K citations

    17

    h-index

  2. WY
    Wenbo Yu

    University of Maryland, Baltimore, United States

    10 publications · 653 citations

    10

    h-index

  3. EP
    E. Prabhu Raman

    University of Maryland, Baltimore, United States

    7 publications · 562 citations

    7

    h-index

  4. SK
    Sirish Kaushik Lakkaraju

    University of Maryland, Baltimore, United States

    6 publications · 452 citations

    6

    h-index

  5. SJ
    Sunhwan Jo

    University of Kansas, United States

    5 publications · 205 citations

    5

    h-index

1–5 of 280

Institutions

103

  1. University of Maryland, Baltimore

    Baltimore, United States

    17 h-index

    56 publications

    3.5K citations

  2. SilcsBio (United States)

    Baltimore, United States

    5 h-index

    11 publications

    487 citations

  3. University of Hong Kong

    Pok Fu Lam, Hong Kong

    5 h-index

    9 publications

    314 citations

  4. Institute for Bioscience and Biotechnology Research

    Rockville, United States

    3 h-index

    13 publications

    290 citations

  5. Baylor College of Medicine

    Houston, United States

    3 h-index

    9 publications

    450 citations

  6. The University of Melbourne

    Melbourne, Australia

    3 h-index

    10 publications

    321 citations

  7. Advanced Bioscience Laboratories (United States)

    Rockville, United States

    3 h-index

    13 publications

    290 citations

  8. University of New England

    Biddeford, United States

    3 h-index

    4 publications

    293 citations

1–8 of 103

Venues

  1. British Journal of Pharmacology

    BJP · 8 publications · 418 citations

    8

    h-index

  2. Journal of Neurochemistry

    JNC · 7 publications · 343 citations

    7

    h-index

  3. Journal of Chemical Information and Modeling

    JCIM · 5 publications · 454 citations

    5

    h-index

  4. 5

    h-index

  5. Journal of Biological Chemistry

    JBC · 4 publications · 175 citations

    4

    h-index

1–5