SilcsBio (United States)

Optimization and Evaluation of Site-Identification by Ligand Competitive Saturation (SILCS) as a Tool for Target-Based Ligand Optimization

Vincent D. Ustach, Sirish Kaushik Lakkaraju, Sunhwan Jo et al. · Journal of Chemical Information and Modeling · 2019 · 81 citations · Full text

Pharmacy, Bioinformatics, Chemistry +17

Identification and characterization of fragment binding sites for allosteric ligand design using the site identification by ligand competitive saturation hotspots approach (SILCS-Hotspots)

Alexander D. MacKerell, Sunhwan Jo, Sirish Kaushik Lakkaraju et al. · Biochimica et Biophysica Acta (BBA) - General Subjects · 2020 · 68 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +17

Rapid and accurate estimation of protein–ligand relative binding affinities using site-identification by ligand competitive saturation

Himanshu Goel, Anthony Hazel, Vincent D. Ustach et al. · Chemical Science · 2021 · 51 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Computational Characterization of Antibody–Excipient Interactions for Rational Excipient Selection Using the Site Identification by Ligand Competitive Saturation-Biologics Approach

Sunhwan Jo, Amy Y. Xu, Joseph E. Curtis et al. · Molecular Pharmaceutics · 2020 · 38 citations · Full text

Pharmacy, Biotechnology, Pharmaceutical Biotechnology +17

Exploring protein‐protein interactions using the site‐identification by ligand competitive saturation methodology

Wenbo Yu, Sunhwan Jo, Sirish Kaushik Lakkaraju et al. · Proteins Structure Function and Bioinformatics · 2018 · 34 citations

Life Sciences, Biochemistry, Bioinformatics +17