Concepedia

Nonlinear Pharmacokinetics

Nonlinear pharmacokinetics is a pharmacokinetic condition in which changes in plasma drug concentration are nonproportional to dose, resulting from saturation of drug-eliminating enzymes, transporters, or plasma protein-binding sites.

567

Publications

26.4K

Citations

2K

Authors

703

Institutions

Publications per year

2017–2026

63

Parents

Children

Publications

567

A pharmacokinetic analysis program (multi) for microcomputer.

Kiyoshi Yamaoka, Yusuke Tanigawara, Terumichi Nakagawa et al. · Journal of Pharmacobio-Dynamics · 1981 · 2.5K citations · Full text

, , +12

An evaluation of R2 as an inadequate measure for nonlinear models in pharmacological and biochemical research: a Monte Carlo approach

Andrej‐Nikolai Spiess, Natalie Neumeyer · BMC Pharmacology · 2010 · 951 citations · Full text

, , +7

Adaptive Rejection Metropolis Sampling within Gibbs Sampling

Walter R. Gilks, Nicky Best, Keith Tan · Journal of the Royal Statistical Society Series C (Applied Statistics) · 1995 · 686 citations

, , +17

Linearized Reference Tissue Parametric Imaging Methods: Application to [ <sup>11</sup> C]DASB Positron Emission Tomography Studies of the Serotonin Transporter in Human Brain

Masanori Ichise, Jeih‐San Liow, Jian‐Qiang Lu et al. · Journal of Cerebral Blood Flow & Metabolism · 2003 · 677 citations · Full text

, , +17

Dose‐Dependent Pharmacokinetics and Psychomotor Effects of Caffeine in Humans

Gary B. Kaplan, David J. Greenblatt, Bruce L. Ehrenberg et al. · The Journal of Clinical Pharmacology · 1997 · 385 citations

, , +13

1–5 of 567

Authors

2K

  1. YS
    Yuichi Sugiyama

    The University of Tokyo, Japan

    12 publications · 419 citations

    11

    h-index

  2. WJ
    William J. Jusko

    University at Buffalo, State University of New York, United States

    11 publications · 664 citations

    11

    h-index

  3. JG
    John G. Wagner

    University of Michigan, United States

    10 publications · 377 citations

    10

    h-index

  4. YS
    Yasufumi Sawada

    The University of Tokyo, Japan

    6 publications · 245 citations

    6

    h-index

  5. PV
    Peter Veng‐Pedersen

    University of Iowa, United States

    6 publications · 191 citations

    6

    h-index

1–5 of 2K

Institutions

703

  1. University at Buffalo, State University of New York

    Buffalo, United States

    21 h-index

    76 publications

    4.5K citations

  2. University of California, San Francisco

    San Francisco, United States

    13 h-index

    41 publications

    4.2K citations

  3. University of Michigan

    Ann Arbor, United States

    12 h-index

    57 publications

    2.9K citations

  4. University of Iowa

    Iowa City, United States

    11 h-index

    29 publications

    923 citations

  5. The University of Tokyo

    Tokyo, Japan

    10 h-index

    29 publications

    1K citations

  6. Inserm

    Paris, France

    10 h-index

    27 publications

    1.9K citations

  7. University of Washington

    Seattle, United States

    8 h-index

    24 publications

    1.3K citations

  8. Novartis (Switzerland)

    Basel, Switzerland

    8 h-index

    12 publications

    883 citations

1–8 of 703

Venues

  1. Clinical Pharmacology & Therapeutics

    CPT · 31 publications · 1.8K citations

    23

    h-index

  2. Journal of Pharmacokinetics and Biopharmaceutics

    26 publications · 1.1K citations

    20

    h-index

  3. Antimicrobial Agents and Chemotherapy

    AAC · 24 publications · 1.4K citations

    18

    h-index

  4. Drug Metabolism and Disposition

    26 publications · 802 citations

    17

    h-index

  5. PubMed

    Repository · 22 publications · 1.3K citations

    17

    h-index

1–5

See also

Nonlinear Pharmacokinetics

Mechanistic Causes

Mathematical Models

Clinical Implications

Assessment Methods