Concepedia

Dose-dependent Clearance

Dose-Dependent Clearance is a pharmacokinetic phenomenon in which the clearance of a drug decreases as the administered dose increases, typically due to saturation of metabolic or excretory mechanisms.

159

Publications

7.4K

Citations

583

Authors

161

Institutions

Publications per year

2017–2026

5

Parents

Children

Publications

159

Clearance concepts in pharmacokinetics

Malcolm Rowland, Leslie Z. Benet, Garry G. Graham · Journal of Pharmacokinetics and Biopharmaceutics · 1973 · 764 citations

, , +10

Effects of concentration-dependent plasma protein binding on ceftriaxone kinetics

K. Stoeckel, Patrick J. McNamara, Roger D. Brandt et al. · Clinical Pharmacology & Therapeutics · 1981 · 204 citations

, , +17

Valproic acid dosage and plasma protein binding and clearance

Andrew Bowdle, Indravadan H. Patel, René H. Levy et al. · Clinical Pharmacology & Therapeutics · 1980 · 147 citations

, , +17

Fluoxetine impairs clearance of alprazolam but not of clonazepam

David J. Greenblatt, Sheldon Preskorn, Monette Cotreau et al. · Clinical Pharmacology & Therapeutics · 1992 · 139 citations

, , +14

Alterations in drug distribution and clearance due to obesity.

D R Abernethy, David J. Greenblatt, Marcia Divoll et al. · Journal of Pharmacology and Experimental Therapeutics · 1981 · 124 citations

, , +12

1–5 of 159

Authors

583

  1. DJ
    David J. Greenblatt

    Tufts University, United States

    10 publications · 500 citations

    10

    h-index

  2. LZ
    Leslie Z. Benet

    University of California, San Francisco, United States

    5 publications · 902 citations

    5

    h-index

  3. RI
    Richard I. Shader

    Tufts University, United States

    4 publications · 236 citations

    4

    h-index

  4. LJ
    Luis Jáuregui

    Mercy St. Vincent Medical Center, United States

    3 publications · 41 citations

    3

    h-index

  5. AR
    Amin Rostami‐Hodjegan

    University of Manchester, United Kingdom

    3 publications · 166 citations

    3

    h-index

1–5 of 583

Institutions

161

  1. Tufts Medical Center

    Boston, United States

    9 h-index

    33 publications

    1.4K citations

  2. University of California, San Francisco

    San Francisco, United States

    7 h-index

    21 publications

    3.4K citations

  3. Tufts University

    Medford, United States

    6 h-index

    24 publications

    1.4K citations

  4. University of Washington

    Seattle, United States

    5 h-index

    14 publications

    877 citations

  5. University of Iowa

    Iowa City, United States

    4 h-index

    18 publications

    885 citations

  6. Flinders Medical Centre

    Bedford Park, Australia

    4 h-index

    13 publications

    855 citations

  7. University of Toledo

    Toledo, United States

    4 h-index

    10 publications

    158 citations

  8. University of Toledo Medical Center

    Toledo, United States

    4 h-index

    13 publications

    357 citations

1–8 of 161

Venues

  1. Clinical Pharmacology & Therapeutics

    CPT · 34 publications · 2.2K citations

    27

    h-index

  2. British Journal of Clinical Pharmacology

    BJCP · 18 publications · 650 citations

    15

    h-index

  3. The Journal of Clinical Pharmacology

    8 publications · 269 citations

    8

    h-index

  4. PubMed

    Repository · 8 publications · 214 citations

    8

    h-index

  5. 7

    h-index

1–5