Concepedia

Extraction Ratio Variability

Extraction Ratio Variability is a pharmacokinetic metric that quantifies the degree to which the hepatic extraction ratio of a drug fluctuates in response to changes in physiological or pathological conditions, thereby distinguishing drugs with concentration-dependent clearance from those exhibiting consistent extraction across dose levels.

7

Publications

219

Citations

21

Authors

10

Institutions

Publications per year

2017–2026

2

Parents

Publications

7

Correlation between in-vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model

Michael S. Roberts, Malcolm Rowland · Journal of Pharmacy and Pharmacology · 1986 · 117 citations

, , +17

Time-dependent variations in the organ extraction ratios of acetaminophen in rat

P M Bélanger, Marcel Lalande, François Doré et al. · Journal of Pharmacokinetics and Biopharmaceutics · 1987 · 25 citations

, , +14

Effect of Methodology in Estimating and Interpreting Water‐Extractable Phosphorus in Animal Manures

Peter A. Vadas, Peter J. A. Kleinman · Journal of Environmental Quality · 2006 · 20 citations

, , +16

Variation in Hepatic Extraction Ratio with Unbound Drug Fraction: Discrimination Between Models of Hepatic Drug Elimination

Amanda Byrne, Denis J. Morgan, Paul M. Harrison et al. · Journal of Pharmaceutical Sciences · 1985 · 19 citations

, , +17

Identifying a long standing error in single-bolus determination of the hepatic extraction ratio for indocyanine green

Eugene H. Wissler · European Journal of Applied Physiology · 2010 · 13 citations

, , +17

1–5 of 7

Authors

21

  1. EH
    Eugene H. Wissler

    The University of Texas at Austin, United States

    1 publications · 13 citations

    1

    h-index

  2. PM
    Paul M. Harrison

    McGill University, Canada

    1 publications · 19 citations

    1

    h-index

  3. LZ
    Lianjie Zhang

    Ningxia University, China

    1 publications · 13 citations

    1

    h-index

  4. ML
    Marcel Lalande

    Université Laval, Canada

    1 publications · 25 citations

    1

    h-index

  5. AB
    Amanda Byrne

    The University of Melbourne, Australia

    1 publications · 19 citations

    1

    h-index

1–5 of 21

Institutions

10

  1. Waters (United States)

    Milford, United States

    1 h-index

    1 publications

    20 citations

  2. The University of Texas at Austin

    Austin, United States

    1 h-index

    1 publications

    13 citations

  3. University of Manchester

    Manchester, United Kingdom

    1 h-index

    1 publications

    117 citations

  4. Luleå University of Technology

    Luleå, Sweden

    1 h-index

    4 publications

    48 citations

  5. U.S. Dairy Forage Research Center

    Madison, United States

    1 h-index

    1 publications

    20 citations

  6. University of Tasmania

    Hobart, Australia

    1 h-index

    1 publications

    117 citations

  7. The Alfred Hospital

    Melbourne, Australia

    1 h-index

    3 publications

    57 citations

  8. Brno University of Technology

    Brno, Czechia

    1 h-index

    1 publications

    13 citations

1–8 of 10

Venues

  1. 1

    h-index

  2. Applied Thermal Engineering

    1 publications · 13 citations

    1

    h-index

  3. European Journal of Applied Physiology

    1 publications · 13 citations

    1

    h-index

  4. 1

    h-index

  5. Journal of Environmental Quality

    JEQ · 1 publications · 20 citations

    1

    h-index

1–5