Concepedia

Hepatic Saturation

Hepatic Saturation is a pharmacokinetic phenomenon in which the liver's capacity to metabolize or clear a drug reaches its maximum due to the saturation of metabolic enzymes or transport proteins, resulting in a nonlinear, dose-dependent increase in systemic drug exposure.

52

Publications

2.7K

Citations

263

Authors

65

Institutions

Publications per year

2017–2026

2

Parents

Publications

52

Hepatic organic anion uptake in the rat.

Bruce F. Scharschmidt, Jeanne G. Waggoner, P D Berk · Journal of Clinical Investigation · 1975 · 251 citations · Full text

, , +14

Saturation of the Reticuloendothelial System with Soluble Immune Complexes

A O Haakenstad, Mart Mannik · The Journal of Immunology · 1974 · 237 citations · Full text

, , +13

Investigation of the Rate-Determining Process in the Hepatic Elimination of HMG-CoA Reductase Inhibitors in Rats and Humans

Takao Watanabe, Hiroyuki Kusuhara, Kazuya Maeda et al. · Drug Metabolism and Disposition · 2009 · 194 citations

, , +17

Haem transport to the liver by haemopexin. Receptor-mediated uptake with recycling of the protein

Ann Smith, William T. Morgan · Biochemical Journal · 1979 · 175 citations · Full text

, , +13

Noninvasive assessment of hepatic lipid composition: Advancing understanding and management of fatty liver disorders

Nathan A. Johnson, David Walton, Toos Sachinwalla et al. · Hepatology · 2008 · 162 citations · Full text

, , +17

1–5 of 52

Authors

263

  1. YS
    Yuichi Sugiyama

    The University of Tokyo, Japan

    3 publications · 305 citations

    3

    h-index

  2. KN
    Koji Nakagawa

    Hokkaido University, Japan

    3 publications · 50 citations

    3

    h-index

  3. NN
    Nobuyuki Nakajima

    Chiba University, Japan

    3 publications · 50 citations

    3

    h-index

  4. HS
    Hiroaki Shimizu

    Chiba University, Japan

    3 publications · 50 citations

    3

    h-index

  5. SA
    Satoshi Ambiru

    Chiba University, Japan

    3 publications · 50 citations

    3

    h-index

1–5 of 263

Institutions

65

  1. The University of Tokyo

    Tokyo, Japan

    4 h-index

    19 publications

    1.3K citations

  2. Chiba University

    Chiba, Japan

    3 h-index

    16 publications

    268 citations

  3. The University of Osaka

    Osaka, Japan

    3 h-index

    14 publications

    307 citations

  4. Saitama Prefecture

    Saitama, Japan

    2 h-index

    10 publications

    365 citations

  5. Kyoto University

    Kyoto, Japan

    2 h-index

    11 publications

    318 citations

  6. Sahlgrenska University Hospital

    Gothenburg, Sweden

    2 h-index

    5 publications

    115 citations

  7. Gunma University

    Maebashi, Japan

    2 h-index

    6 publications

    219 citations

  8. Osaka City University

    Osaka, Japan

    2 h-index

    2 publications

    49 citations

1–8 of 65

Venues

  1. PubMed

    Repository · 5 publications · 197 citations

    5

    h-index

  2. Hepatology

    4 publications · 318 citations

    4

    h-index

  3. Critical Care Medicine

    3 publications · 144 citations

    3

    h-index

  4. 2

    h-index

  5. Transplantation

    2 publications · 40 citations

    2

    h-index

1–5