Concepedia

Model-based Dose Individualization

Model-Based Dose Individualization is a pharmacokinetic modeling strategy that employs population pharmacokinetic models and Bayesian inference to tailor drug dosing regimens to individual patients by updating prior expectations with patient-specific data to optimize therapeutic outcomes.

59

Publications

3K

Citations

317

Authors

142

Institutions

Publications per year

2017–2026

19

Variants

MipdModel-informed Precision Dosing

Parents

Publications

59

Bayesian Individualization of Pharmacokinetics: Simple Implementation and Comparison with Non-Bayesian Methods

Lewis B. Sheiner, Stuart L. Beal · Journal of Pharmaceutical Sciences · 1982 · 301 citations

, , +16

Application of Physiologically Based Pharmacokinetic (PBPK) Modeling to Support Dose Selection: Report of an FDA Public Workshop on PBPK

Christian Wagner, Ping Zhao, Y. Pan et al. · CPT Pharmacometrics & Systems Pharmacology · 2015 · 268 citations · Full text

, , +13

A Prospective, Randomized Pilot Trial of Model-Based Warfarin Dose Initiation using CYP2C9 Genotype and Clinical Data

Michael A Hillman, Russell A. Wilke, Steven H. Yale et al. · Clinical Medicine & Research · 2005 · 196 citations · Full text

, , +15

Optimal medication dosing from suboptimal clinical examples: A deep reinforcement learning approach

Shamim Nemati, Mohammad M. Ghassemi, Gari D. Clifford · 2016 · 194 citations

, , +16

Individualizing drug dosage regimens: roles of population pharmacokinetic and dynamic models, Bayesian fitting, and adaptive control.

Roger W. Jelliffe, Alan Schumitzky, M. Van Guilder et al. · PubMed · 1993 · 150 citations

, , +17

1–5 of 59

Authors

317

  1. SB
    Stephen B. Duffull

    University of Otago, New Zealand

    4 publications · 179 citations

    4

    h-index

  2. EJ
    Evan J. Begg

    Christchurch Hospital, New Zealand

    2 publications · 99 citations

    2

    h-index

  3. MK
    Masato Kaneko

    Bayer (Japan), Japan

    2 publications · 165 citations

    2

    h-index

  4. WM
    Wolfgang Mueck

    Bayer (Germany), Germany

    2 publications · 165 citations

    2

    h-index

  5. MK
    Mariko Kajikawa

    Bayer (Japan), Japan

    2 publications · 165 citations

    2

    h-index

1–5 of 317

Institutions

142

  1. Uppsala University

    Uppsala, Sweden

    8 h-index

    20 publications

    745 citations

  2. University of Manchester

    Manchester, United Kingdom

    4 h-index

    4 publications

    161 citations

  3. Impact

    Ottawa, Canada

    2 h-index

    3 publications

    88 citations

  4. United States Food and Drug Administration

    Silver Spring, United States

    2 h-index

    10 publications

    1.9K citations

  5. University of Southern California

    Los Angeles, United States

    2 h-index

    5 publications

    410 citations

  6. McMaster University

    Hamilton, Canada

    2 h-index

    3 publications

    88 citations

  7. Gazi University

    Ankara, Turkey

    2 h-index

    3 publications

    154 citations

  8. Bayer (Germany)

    Leverkusen, Germany

    2 h-index

    4 publications

    330 citations

1–8 of 142

Venues

  1. Clinical Pharmacokinetics

    4 publications · 103 citations

    4

    h-index

  2. Clinical Pharmacology & Therapeutics

    CPT · 4 publications · 205 citations

    4

    h-index

  3. Frontiers in Pharmacology

    2 publications · 32 citations

    3

    h-index

  4. British Journal of Clinical Pharmacology

    BJCP · 2 publications · 87 citations

    2

    h-index

  5. Drug Metabolism and Pharmacokinetics

    DMPK · 2 publications · 165 citations

    2

    h-index

1–5