Concepedia

Ectodomain Shedding

Ectodomain Shedding is a proteolytic processing mechanism in which the extracellular domain of a transmembrane protein is selectively cleaved and released by specific proteases, thereby modulating cellular signaling and membrane protein function.

469

Publications

37.7K

Citations

2.5K

Authors

743

Institutions

Publications per year

2017–2026

67

Parents

Publications

469

An Essential Role for Ectodomain Shedding in Mammalian Development

Jacques J. Peschon, Jennifer L. Slack, P. Linga Reddy et al. · Science · 1998 · 1.6K citations

, , +10

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

Umut Şahin, Gisela Weskamp, Kristine Kelly et al. · The Journal of Cell Biology · 2004 · 986 citations

, , +11

Tumor Necrosis Factor-α Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2)

D Lambert, Mike Yarski, Fiona J. Warner et al. · Journal of Biological Chemistry · 2005 · 712 citations · Full text

, , +11

Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1

Veerle Noë, Barbara Fingleton, Kathleen Jacobs et al. · Journal of Cell Science · 2001 · 688 citations

, , +17

A metalloprotease–disintegrin, MDC9/meltrin‐γ/ADAM9 and PKCδ are involved in TPA‐induced ectodomain shedding of membrane‐anchored heparin‐binding EGF‐like growth factor

Yasushi Izumi · The EMBO Journal · 1998 · 518 citations

, , +7

1–5 of 469

Authors

2.5K

  1. CB
    Carl Blobel

    Cornell University, United States

    26 publications · 4K citations

    24

    h-index

  2. SH
    Shigeki Higashiyama

    Ehime University, Japan

    19 publications · 2.2K citations

    16

    h-index

  3. PS
    Paul Säftig

    Christian-Albrechts-Universität zu Kiel, Germany

    15 publications · 2.6K citations

    15

    h-index

  4. SR
    Stefan Rose‐John

    Christian-Albrechts-Universität zu Kiel, Germany

    16 publications · 909 citations

    15

    h-index

  5. SF
    Stefan F. Lichtenthaler

    German Center for Neurodegenerative Diseases, Germany

    9 publications · 708 citations

    9

    h-index

1–5 of 2.5K

Institutions

743

  1. Christian-Albrechts-Universität zu Kiel

    Kiel, Germany

    28 h-index

    178 publications

    10.9K citations

  2. Cornell University

    Ithaca, United States

    20 h-index

    41 publications

    4.6K citations

  3. Harvard University

    Cambridge, United States

    20 h-index

    63 publications

    6.5K citations

  4. The University of Osaka

    Osaka, Japan

    17 h-index

    72 publications

    7.7K citations

  5. Hospital for Special Surgery

    New York, United States

    16 h-index

    48 publications

    4.4K citations

  6. Ehime University

    Matsuyama, Japan

    15 h-index

    59 publications

    4.5K citations

  7. Kyoto University

    Kyoto, Japan

    13 h-index

    77 publications

    2.9K citations

  8. Ludwig-Maximilians-Universität München

    Munich, Germany

    12 h-index

    69 publications

    9.5K citations

1–8 of 743

Venues

  1. Journal of Biological Chemistry

    JBC · 100 publications · 10K citations

    60

    h-index

  2. Biochemical Journal

    BJ · 18 publications · 1.3K citations

    17

    h-index

  3. Journal of Cell Science

    15 publications · 1.9K citations

    15

    h-index

  4. The Journal of Immunology

    JI · 15 publications · 1.3K citations

    15

    h-index

  5. Journal of Neurochemistry

    JNC · 11 publications · 483 citations

    11

    h-index

1–5