Shigeki Higashiyama

A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

Shigeki Higashiyama, Judith A. Abraham, John C. Fiddes et al. · Science · 1991 · 1.1K citations

Epidermal Growth Factor, Immunology, Heparin-binding Growth Factor +19

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

Umut Şahin, Gisela Weskamp, Kristine Kelly et al. · The Journal of Cell Biology · 2004 · 980 citations · Full text

Protein Function, Signal Transduction, Signaling Pathway +12

Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

Masanori Asakura, Masafumi Kitakaze, Seiji Takashima et al. · Nature Medicine · 2002 · 718 citations

Adam12 Processing, Cardiac Muscle, Cardiomyopathy +9

Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with cell surface heparan sulfate

Shigeki Higashiyama, JA Abraham, Michael Klagsbrun · The Journal of Cell Biology · 1993 · 365 citations · Full text

Cell Adhesion, Glycobiology, Cell Proliferation +19

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

Asuka Inoue, Jun Ishiguro, Hajime Kitamura et al. · Nature Methods · 2012 · 357 citations

Biomarker (Medicine), Signal Transduction, Engineering +9