Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

Umut Şahin, Gisela Weskamp, Kristine Kelly, +6

The Journal of Cell Biology

Protein FunctionSignal TransductionSignaling PathwayMedicineEgfr Ligand Sheddases +10

Oxidative stress–induced assembly of PML nuclear bodies controls sumoylation of partner proteins

Umut Şahin, Omar Ferhi, Marion Jeanne, +8

The Journal of Cell Biology

Partner ProteinsMolecular BiologyRedox BiologyOxidative StressTranscriptional Regulation +18

Essential Role for ADAM19 in Cardiovascular Morphogenesis

Hong-Ming Zhou, Gisela Weskamp, Valérie Chesneau, +12

Molecular and Cellular Biology

Ectodomain shedding of the EGF‐receptor ligand epigen is mediated by ADAM17

Umut Şahin, Carl Blobel

FEBS Letters

Ectodomain SheddingCell GrowthTranscriptional RegulationTissue DevelopmentSignaling Pathway +17

Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells

Hiba El Hajj, Zeina Dassouki, Caroline Berthier, +14

Blood

ATL response to arsenic/interferon therapy is triggered by SUMO/PML/RNF4-dependent Tax degradation

Zeina Dassouki, Umut Şahin, Hiba El Hajj, +6

Blood

Interferon controls SUMO availability via the Lin28 and let-7 axis to impede virus replication

Umut Şahin, Omar Ferhi, Xavier Carnec, +6

Nature Communications

Virus ReplicationViral ReplicationSumo AvailabilityMolecular VirologyPathogenesis +8

A Sensitive Method to Monitor Ectodomain Shedding of Ligands of the Epidermal Growth Factor Receptor

Umut Şahin, Gisela Weskamp, Yufang Zheng, +3

Humana Press eBooks

Human GrowthImmunologyEctodomain SheddingEgfr LigandsDermatology +17

Sumoylation of Human Argonaute 2 at Lysine-402 Regulates Its Stability

Umut Şahin, Pierre Lapaquette, Alexandra Andrieux, +2

PLoS ONE

Molecular RegulationGeneticsMolecular BiologyEpigeneticsCellular Physiology +20

Characterization of the catalytic properties of the membrane-anchored metalloproteinase ADAM9 in cell-based assays

Thorsten Maretzky, Steven Swendeman, Elin Mogollon, +3

Biochemical Journal

Molecular BiologyMetalloprotease 9Membrane-anchored Metalloproteinase Adam9Signaling PathwayMembrane-anchored Metalloproteinase +17