Concepedia

Dose-dependent Selectivity

Dose-Dependent Selectivity is a pharmacological principle denoting the phenomenon whereby the selectivity of a drug for a specific tissue or target varies as a function of administered dose, distinguishing it from static selectivity models by incorporating dose-related shifts in binding affinity, distribution, or downstream effects.

241

Publications

14.2K

Citations

1.7K

Authors

370

Institutions

Publications per year

2017–2026

44

Parents

Publications

241

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

Kyle V. Butler, Jay H. Kalin, Camille Brochier et al. · Journal of the American Chemical Society · 2010 · 772 citations · Full text

, , +16

Blockade of Effects of Smoked Marijuana by the CB1-Selective Cannabinoid Receptor Antagonist SR141716

Marilyn A. Huestis, David A. Gorelick, Stephen J. Heishman et al. · Archives of General Psychiatry · 2001 · 483 citations

, , +14

Preclinical Pharmacology of AZD5363, an Inhibitor of AKT: Pharmacodynamics, Antitumor Activity, and Correlation of Monotherapy Activity with Genetic Background

Barry R. Davies, Hannah E. Greenwood, Phillippa Dudley et al. · Molecular Cancer Therapeutics · 2012 · 461 citations · Full text

, , +16

17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts.

David B. Solit, Fuzhong F. Zheng, Pamela N. Münster et al. · PubMed · 2002 · 435 citations

, , +17

Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension

Mason W. Freeman, Yuan‐Di C. Halvorsen, William Marshall et al. · New England Journal of Medicine · 2022 · 352 citations · Full text

, , +17

1–5 of 241

Authors

1.7K

  1. TL
    Tony L. Yaksh

    University of California San Diego, United States

    3 publications · 296 citations

    3

    h-index

  2. NA
    Nancy A. Ator

    Johns Hopkins University, United States

    3 publications · 67 citations

    3

    h-index

  3. ED
    Erik De Clercq

    Rega Institute for Medical Research, Belgium

    3 publications · 555 citations

    3

    h-index

  4. HS
    Huub Schellekens

    Utrecht University, Netherlands

    2 publications · 337 citations

    2

    h-index

  5. HN
    Hidehiko Nakagawa

    Nagoya City University, Japan

    2 publications · 230 citations

    2

    h-index

1–5 of 1.7K

Institutions

370

  1. Johns Hopkins University

    Baltimore, United States

    7 h-index

    13 publications

    549 citations

  2. University of California San Diego

    San Diego, United States

    7 h-index

    14 publications

    1.2K citations

  3. National Institutes of Health

    Bethesda, United States

    7 h-index

    33 publications

    4.4K citations

  4. Johns Hopkins Medicine

    Baltimore, United States

    5 h-index

    7 publications

    281 citations

  5. Sapienza University of Rome

    Rome, Italy

    4 h-index

    21 publications

    463 citations

  6. Virginia Commonwealth University

    Richmond, United States

    4 h-index

    7 publications

    245 citations

  7. Novartis (Switzerland)

    Basel, Switzerland

    3 h-index

    17 publications

    567 citations

  8. National Cancer Institute

    Bethesda, United States

    3 h-index

    8 publications

    1.6K citations

1–8 of 370

Venues

  1. PubMed

    Repository · 24 publications · 1.6K citations

    20

    h-index

  2. 20

    h-index

  3. Journal of Medicinal Chemistry

    17 publications · 698 citations

    17

    h-index

  4. PLoS ONE

    6 publications · 273 citations

    6

    h-index

  5. ACS Medicinal Chemistry Letters

    6 publications · 189 citations

    6

    h-index

1–5