Concepedia

Dose-dependent Off-target Effects

Dose-Dependent Off-Target Effects is an off-target effect characterized by its increasing likelihood or severity in response to higher doses of a therapeutic agent, distinguishing it from dose-independent off-target interactions by its direct quantitative relationship with administered dosage.

71

Publications

4.9K

Citations

498

Authors

227

Institutions

Publications per year

2017–2026

32

Parents

Publications

71

Noise amidst the silence: off-target effects of siRNAs?

Aimee L. Jackson, Peter S. Linsley · Trends in Genetics · 2004 · 365 citations

, , +6

Pitfalls of the MTT assay: Direct and off-target effects of inhibitors can result in over/underestimation of cell viability

Aleksei A. Stepanenko, V. V. Dmitrenko · Gene · 2015 · 306 citations

, , +8

Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays

Meghana Kulkarni, Matthew A. Booker, Serena J. Silver et al. · Nature Methods · 2006 · 300 citations

, , +15

Prevalence of off-target effects in Drosophila RNA interference screens

Yong Ma, Adrian Creanga, Lawrence Lum et al. · Nature · 2006 · 297 citations

, , +10

Identifying off-target effects and hidden phenotypes of drugs in human cells

Marnie L. MacDonald, Jane E. Lamerdin, Stephen Owens et al. · Nature Chemical Biology · 2006 · 297 citations

, , +16

1–5 of 71

Authors

498

  1. MK
    Mark K. Schlegel

    Alnylam Pharmaceuticals (United States), United States

    2 publications · 356 citations

    2

    h-index

  2. SR
    Subba Reddy Palli

    University of Kentucky, United States

    2 publications · 72 citations

    2

    h-index

  3. SB
    Simone Boehrer

    Goethe University Frankfurt, Germany

    2 publications · 123 citations

    2

    h-index

  4. VO
    Vedat O. Yilmaz

    Allen Institute, United States

    2 publications · 356 citations

    2

    h-index

  5. YJ
    Yongfeng Jiang

    Alnylam Pharmaceuticals (United States), United States

    2 publications · 356 citations

    2

    h-index

1–5 of 498

Institutions

227

  1. The University of Melbourne

    Melbourne, Australia

    4 h-index

    15 publications

    602 citations

  2. Karolinska Institutet

    Stockholm, Sweden

    4 h-index

    29 publications

    2.3K citations

  3. Monash University

    Melbourne, Australia

    4 h-index

    10 publications

    367 citations

  4. Stanford University

    Stanford, United States

    3 h-index

    26 publications

    3.3K citations

  5. Institut Gustave Roussy

    Villejuif, France

    2 h-index

    13 publications

    1.1K citations

  6. St Vincent's Hospital Melbourne

    Melbourne, Australia

    2 h-index

    4 publications

    142 citations

  7. Chinese Academy of Medical Sciences & Peking Union Medical College

    Beijing, China

    2 h-index

    17 publications

    1.2K citations

  8. University of Copenhagen

    Copenhagen, Denmark

    2 h-index

    3 publications

    107 citations

1–8 of 227

Venues

  1. Scientific Reports

    7 publications · 302 citations

    7

    h-index

  2. Methods in molecular biology

    Book series · 3 publications · 120 citations

    3

    h-index

  3. PLoS ONE

    3 publications · 350 citations

    3

    h-index

  4. Molecular Cancer Therapeutics

    MCT · 2 publications · 120 citations

    2

    h-index

  5. British Journal of Clinical Pharmacology

    BJCP · 2 publications · 77 citations

    2

    h-index

1–5