Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

David A. Barbie, Pablo Tamayo, Jesse S. Boehm, +32

Nature

Systems BiologyOncogenic AgentMedicineKras-driven CancersCancer Biology +2

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles

Aravind Subramanian, Rajiv Narayan, Steven M. Corsello, +53

Cell

Network ScienceEngineeringData ScienceEdge ComputingComputer Engineering +10

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

Lauren L Campbell Marotta, Vanessa Almendro, Andriy Marusyk, +25

Journal of Clinical Investigation

Breast OncologyImmunologyCell ProliferationCancer BiologyTumor Biology +19

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

Jordi Barretina, Barry S. Taylor, Shantanu Banerji, +42

Nature Genetics

Tumor HeterogeneityMedicinePathologyCancer GenomicsSubtype-specific Genomic Alterations +4

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

E. Robert McDonald, Antoine de Weck, Michael R. Schlabach, +96

Cell

BioinformaticsTumor BiologyRadiation OncologyFunctional GenomicsProject Drive +11

CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

Ron Firestein, Adam J. Bass, So Young Kim, +25

Nature

Tumor BiologyOncologyOncogenic AgentMedicineColorectal Cancer +8

A public genome-scale lentiviral expression library of human ORFs

Xiaoping Yang, Jesse S. Boehm, Xinping Yang, +21

Nature Methods

Functional GenomicsHuman OrfsGene Sequence AnnotationGeneticsComputational Genomics +5

Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells

Claudia Scholl, Stefan Fröhling, Ian F. Dunn, +15

Cell

Cell RegulationOncogenic AgentMedicineSynthetic Lethal InteractionReceptor Tyrosine Kinase +8

Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning

Thouis R. Jones, Anne E. Carpenter, Michael R. Lamprecht, +8

Proceedings of the National Academy of Sciences

Multiple Instance LearningEngineeringMachine LearningDigital PathologyDiverse Cellular Morphologies +22

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

Birgit Knoechel, Justine E. Roderick, Kaylyn E. Williamson, +24

Nature Genetics

Hematological MalignancyChromatinMixed-phenotype Acute LeukemiaEpigenetic ChangeMalignant Blood Disorder +9