Lawrence Lum

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

Baozhi Chen, Michael Dodge, Wei‐Jen Tang et al. · Nature Chemical Biology · 2009 · 1.4K citations · Full text

Signal Transduction, Signaling Pathway, Medicine +9

Identification of Hedgehog Pathway Components by RNAi in <i>Drosophila</i> Cultured Cells

Lawrence Lum, Shenqin Yao, Brian A. Mozer et al. · Science · 2003 · 516 citations

Cell Lineage, Hedgehog Pathway Components, Developmental Biology +13

Minimizing the risk of reporting false positives in large-scale RNAi screens

Christophe J. Echeverri, Philip A. Beachy, Buzz Baum et al. · Nature Methods · 2006 · 432 citations · Full text

Functional Genomics, Nucleic Acid Biomarkers, Genetics +8

Evidence for a Role of a Tumor Necrosis Factor-α (TNF-α)-converting Enzyme-like Protease in Shedding of TRANCE, a TNF Family Member Involved in Osteoclastogenesis and Dendritic Cell Survival

Lawrence Lum, Brian Wong, Régis Josien et al. · Journal of Biological Chemistry · 1999 · 407 citations · Full text

Prevalence of off-target effects in Drosophila RNA interference screens

Yong Ma, Adrian Creanga, Lawrence Lum et al. · Nature · 2006 · 294 citations

Genetics, Genomic Mechanism, Off-target Effects +4