Concepedia

Crispr-based Ocular Therapy

CRISPR-Based Ocular Therapy is a gene-editing intervention that employs CRISPR-Cas systems to precisely modify genetic sequences within ocular tissues for the treatment of inherited or acquired eye disorders.

32

Publications

3.1K

Citations

251

Authors

83

Institutions

Publications per year

2017–2026

28

Parents

Publications

32

Gene therapy restores vision in a canine model of childhood blindness

Gregory M. Acland, Jharna Ray, Qí Zhāng et al. · Nature Genetics · 2001 · 1.2K citations

, , +16

Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10

Morgan L. Maeder, Michael Stefanidakis, Christopher J. Wilson et al. · Nature Medicine · 2019 · 706 citations

, , +16

Genome surgery using Cas9 ribonucleoproteins for the treatment of age-related macular degeneration

Kyoungmi Kim, Sung Wook Park, Jin Hyoung Kim et al. · Genome Research · 2017 · 167 citations · Full text

, , +17

Cas9/sgRNA selective targeting of the P23H Rhodopsin mutant allele for treating retinitis pigmentosa by intravitreal AAV9.PHP.B-based delivery

Serena Giannelli, Mirko Luoni, Valerio Castoldi et al. · Human Molecular Genetics · 2017 · 130 citations · Full text

, , +17

CRISPR-LbCpf1 prevents choroidal neovascularization in a mouse model of age-related macular degeneration

Taeyoung Koo, Sung Wook Park, Dong Hyun Jo et al. · Nature Communications · 2018 · 100 citations · Full text

, , +17

1–5 of 32

Authors

251

  1. TJ
    Thomas J. Corydon

    Aarhus University, Denmark

    3 publications · 121 citations

    3

    h-index

  2. RR
    Robin R. Ali

    University College London, United Kingdom

    3 publications · 147 citations

    3

    h-index

  3. AL
    Anne Louise Askou

    Aarhus University, Denmark

    3 publications · 121 citations

    3

    h-index

  4. DK
    Daesik Kim

    Seoul National University, South Korea

    2 publications · 267 citations

    2

    h-index

  5. JH
    Jin Hyoung Kim

    Seoul National University Hospital, South Korea

    2 publications · 267 citations

    2

    h-index

1–5 of 251

Institutions

83

  1. University College London

    London, United Kingdom

    4 h-index

    8 publications

    482 citations

  2. Aarhus University

    Aarhus, Denmark

    3 h-index

    12 publications

    618 citations

  3. University of Iowa

    Iowa City, United States

    3 h-index

    7 publications

    128 citations

  4. Aarhus University Hospital

    Aarhus, Denmark

    3 h-index

    5 publications

    231 citations

  5. University of Florida

    Gainesville, United States

    2 h-index

    2 publications

    1.2K citations

  6. Jinan University

    Guangzhou, China

    2 h-index

    4 publications

    96 citations

  7. Smith-Kettlewell Eye Research Institute

    San Francisco, United States

    2 h-index

    8 publications

    140 citations

  8. Moorfields Eye Hospital NHS Foundation Trust

    London, United Kingdom

    2 h-index

    5 publications

    306 citations

1–8 of 83

Venues

  1. Gene Therapy

    4 publications · 105 citations

    4

    h-index

  2. Methods in molecular biology

    Book series · 2 publications · 31 citations

    2

    h-index

  3. Molecular Therapy

    2 publications · 127 citations

    2

    h-index

  4. Investigative Ophthalmology & Visual Science

    IOVS · 2 publications · 38 citations

    2

    h-index

  5. Scientific Reports

    2 publications · 41 citations

    2

    h-index

1–5