Mirko Luoni

Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity

Simone Bido, Sharon Muggeo, Luca Massimino et al. · Nature Communications · 2021 · 175 citations · Full text

Cas9/sgRNA selective targeting of the P23H Rhodopsin mutant allele for treating retinitis pigmentosa by intravitreal AAV9.PHP.B-based delivery

Serena Giannelli, Mirko Luoni, Valerio Castoldi et al. · Human Molecular Genetics · 2017 · 128 citations · Full text

Ocular Disease, Immunology, Molecular Biology +19

AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy

Giuseppe Morabito, Serena Giannelli, Gabriele Ordazzo et al. · Molecular Therapy · 2017 · 126 citations · Full text

Frataxin gene editing rescues Friedreich’s ataxia pathology in dorsal root ganglia organoid-derived sensory neurons

Pietro Giuseppe Mazzara, Sharon Muggeo, Mirko Luoni et al. · Nature Communications · 2020 · 77 citations · Full text

Scn1a gene reactivation after symptom onset rescues pathological phenotypes in a mouse model of Dravet syndrome

Nicholas Valassina, Simone Brusco, Alessia Salamone et al. · Nature Communications · 2022 · 69 citations · Full text