Concepedia

Crispr-based Gene Circuits

CRISPR-Based Gene Circuits is a synthetic biological framework that integrates CRISPR-Cas gene-editing components into engineered regulatory networks to enable programmable, sequence-specific control of gene expression dynamics in living cells.

66

Publications

5.5K

Citations

369

Authors

135

Institutions

Publications per year

2017–2026

55

Variants

Crispr Gene Circuits

Parents

Publications

66

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function

Eric Shifrut, Julia Carnevale, Victoria Tobin et al. · Cell · 2018 · 567 citations · Full text

, , +17

Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

Zachary Steinhart, Zvezdan Pavlovic, Megha Chandrashekhar et al. · Nature Medicine · 2016 · 319 citations

, , +17

Integrating CRISPR-Cas12a with a DNA circuit as a generic sensing platform for amplified detection of microRNA

Shuang Peng, Zhen Tan, Siyu Chen et al. · Chemical Science · 2020 · 273 citations · Full text

, , +14

Multi‐input CRISPR/Cas genetic circuits that interface host regulatory networks

Alec AK Nielsen, Christopher A. Voigt · Molecular Systems Biology · 2014 · 262 citations · Full text

, , +17

Digital logic circuits in yeast with CRISPR-dCas9 NOR gates

Miles Gander, Justin D. Vrana, William E. Voje et al. · Nature Communications · 2017 · 247 citations · Full text

, , +17

1–5 of 66

Authors

369

  1. JM
    James M. Carothers

    University of Washington, United States

    4 publications · 386 citations

    4

    h-index

  2. YL
    Yuchen Liu

    Shenzhen Second People's Hospital, China

    4 publications · 338 citations

    4

    h-index

  3. WH
    Weiren Huang

    Shenzhen Second People's Hospital, China

    4 publications · 338 citations

    4

    h-index

  4. LS
    Lei S. Qi

    Stanford University, United States

    3 publications · 313 citations

    3

    h-index

  5. ZC
    Zhiming Cai

    Shenzhen Second People's Hospital, China

    3 publications · 292 citations

    3

    h-index

1–5 of 369

Institutions

135

  1. Massachusetts Institute of Technology

    Cambridge, United States

    5 h-index

    20 publications

    2.3K citations

  2. University of Washington

    Seattle, United States

    4 h-index

    24 publications

    2.1K citations

  3. Shenzhen Second People's Hospital

    Shenzhen, China

    4 h-index

    21 publications

    2.1K citations

  4. Harry Perkins Institute of Medical Research

    Nedlands, Australia

    3 h-index

    17 publications

    455 citations

  5. The University of Western Australia

    Perth, Australia

    3 h-index

    33 publications

    1K citations

  6. University of California, San Francisco

    San Francisco, United States

    3 h-index

    15 publications

    5.9K citations

  7. ETH Zurich

    Zurich, Switzerland

    3 h-index

    7 publications

    600 citations

  8. ARC Centre of Excellence in Synthetic Biology

    Sydney, Australia

    3 h-index

    10 publications

    246 citations

1–8 of 135

Venues

  1. Nature Communications

    17 publications · 1.7K citations

    17

    h-index

  2. ACS Synthetic Biology

    6 publications · 220 citations

    6

    h-index

  3. Nucleic Acids Research

    5 publications · 194 citations

    4

    h-index

  4. Biotechnology Journal

    2 publications · 87 citations

    2

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 107 citations

    2

    h-index

1–5