Concepedia

Codon Optimality

Codon Optimality is a theoretical construct in molecular genetics that quantifies the efficiency and accuracy of codon–tRNA interactions during translation, distinguishing itself from related metrics by its integration of tRNA abundance, codon usage bias, and their collective impact on mRNA stability and translational kinetics.

238

Publications

22.6K

Citations

911

Authors

335

Institutions

Publications per year

2017–2026

81

Parents

Publications

238

The ‘effective number of codons’ used in a gene

Frank Wright · Gene · 1990 · 2.4K citations

, , +9

Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: A proposal for a synonymous codon choice that is optimal for the E. coli translational system

Toshimichi Ikemura · Journal of Molecular Biology · 1981 · 1.5K citations

, , +17

Codon usage in yeast: cluster analysis clearly differentiates highly and lowly expressed genes

Paul M. Sharp, Thérèse M.F. Tuohy, Krzysztof Mosurski · Nucleic Acids Research · 1986 · 1.3K citations · Full text

, , +14

Codon Optimality Is a Major Determinant of mRNA Stability

Vladimir Presnyak, Najwa Alhusaini, Ying-Hsin Chen et al. · Cell · 2015 · 1.1K citations · Full text

, , +16

Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding

Sebastian Pechmann, Judith Frydman · Nature Structural & Molecular Biology · 2012 · 535 citations · Full text

, , +16

1–5 of 238

Authors

911

  1. PM
    Paul M. Sharp

    Trinity College Dublin, Ireland

    6 publications · 1.7K citations

    6

    h-index

  2. YL
    Yi Liu

    The University of Texas Southwestern Medical Center, United States

    6 publications · 866 citations

    6

    h-index

  3. JC
    Jeff Coller

    Case Western Reserve University, United States

    5 publications · 1.6K citations

    5

    h-index

  4. AF
    Anders Fuglsang

    University of Copenhagen, Denmark

    4 publications · 266 citations

    4

    h-index

  5. MZ
    Mian Zhou

    Feinstein Institute for Medical Research, United States

    4 publications · 645 citations

    4

    h-index

1–5 of 911

Institutions

335

  1. Harvard University

    Cambridge, United States

    7 h-index

    20 publications

    1.7K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    7 h-index

    29 publications

    1.6K citations

  3. National Institutes of Health

    Bethesda, United States

    6 h-index

    35 publications

    2.2K citations

  4. The University of Texas Southwestern Medical Center

    Dallas, United States

    6 h-index

    22 publications

    3.7K citations

  5. Trinity College Dublin

    Dublin, Ireland

    5 h-index

    11 publications

    5K citations

  6. Stanford University

    Stanford, United States

    5 h-index

    12 publications

    3.1K citations

  7. Case Western Reserve University

    Cleveland, United States

    5 h-index

    24 publications

    11.1K citations

  8. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    12 publications

    1.7K citations

1–8 of 335

Venues

  1. Nucleic Acids Research

    18 publications · 3.1K citations

    17

    h-index

  2. PLoS ONE

    9 publications · 340 citations

    9

    h-index

  3. Molecular Biology and Evolution

    MBE · 9 publications · 698 citations

    9

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 8 publications · 1.1K citations

    8

    h-index

  5. Scientific Reports

    9 publications · 369 citations

    8

    h-index

1–5