Vladimir Presnyak

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

Kizzmekia S. Corbett, Darin K. Edwards, Sarah R. Leist et al. · Nature · 2020 · 1.6K citations · Full text

Vaccination, Prototype Pathogen Preparedness, Vaccine Development +6

Codon Optimality Is a Major Determinant of mRNA Stability

Vladimir Presnyak, Najwa Alhusaini, Ying-Hsin Chen et al. · Cell · 2015 · 1.1K citations · Full text

Systems Biology, Genetics, Rna Structure Prediction +2

mRNA structure regulates protein expression through changes in functional half-life

David Mauger, B. Joseph Cabral, Vladimir Presnyak et al. · Proceedings of the National Academy of Sciences · 2019 · 529 citations · Full text

Molecular Biology, Codon Usage, Protein Expression +16

Human 5′ UTR design and variant effect prediction from a massively parallel translation assay

Paul Sample, Ban Wang, David W. Reid et al. · Nature Biotechnology · 2019 · 431 citations · Full text

Functional Genomics, Next-generation Sequencing, Genetics +8

N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density

Yuri V. Svitkin, Yi Cheng, Tirtha Chakraborty et al. · Nucleic Acids Research · 2017 · 254 citations · Full text

Translation Process, Molecular Biology, Protein Synthesis +16