Concepedia

Chaperone-substrate Recognition

Chaperone-Substrate Recognition is a molecular interaction mechanism by which chaperone proteins selectively identify and bind non-native or misfolded protein substrates through exposed hydrophobic regions or specific sequence motifs, thereby initiating proper folding, preventing aggregation, or targeting for degradation.

875

Publications

70.2K

Citations

3.6K

Authors

945

Institutions

Publications per year

2017–2026

141

Parents

Publications

875

Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

Chrisostomos Prodromou, S. Mark Roe, Ronan O’Brien et al. · Cell · 1997 · 1.3K citations · Full text

, , +16

Molecular Chaperones Hsp90 and Hsp70 Deliver Preproteins to the Mitochondrial Import Receptor Tom70

Jason C. Young, Nicholas J. Hoogenraad, F. Ulrich Hartl · Cell · 2003 · 918 citations · Full text

, , +17

Proteins as molecular chaperones

John Ellis · Nature · 1987 · 916 citations

, , +12

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

Mikko Taipale, Irina Krykbaeva, Martina Koeva et al. · Cell · 2012 · 903 citations · Full text

, , +16

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

Geoffrey C. Meacham, Cam Patterson, Wenyue Zhang et al. · Nature Cell Biology · 2000 · 837 citations

, , +16

1–5 of 875

Authors

3.6K

  1. BB
    Bernd Bukau

    Heidelberg University, Germany

    29 publications · 4.9K citations

    24

    h-index

  2. JB
    Johannes Büchner

    Technical University of Munich, Germany

    18 publications · 1.6K citations

    18

    h-index

  3. JC
    James C.A. Bardwell

    University of Michigan, United States

    14 publications · 1.3K citations

    13

    h-index

  4. SW
    Sue Wickner

    National Institutes of Health, United States

    12 publications · 935 citations

    12

    h-index

  5. AM
    Axel Mogk

    Heidelberg University, Germany

    12 publications · 1.5K citations

    12

    h-index

1–5 of 3.6K

Institutions

945

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    34 h-index

    98 publications

    10.9K citations

  2. National Institutes of Health

    Bethesda, United States

    29 h-index

    137 publications

    11.6K citations

  3. University of Michigan

    Ann Arbor, United States

    25 h-index

    127 publications

    11.8K citations

  4. Heidelberg University

    Heidelberg, Germany

    25 h-index

    127 publications

    20.2K citations

  5. Technical University of Munich

    Munich, Germany

    20 h-index

    114 publications

    9.1K citations

  6. University of Toronto

    Toronto, Canada

    20 h-index

    88 publications

    15.8K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    18 h-index

    109 publications

    5.1K citations

  8. Max Planck Institute of Biochemistry

    Martinsried, Germany

    16 h-index

    39 publications

    9.1K citations

1–8 of 945

Venues

  1. Journal of Biological Chemistry

    JBC · 137 publications · 9.5K citations

    61

    h-index

  2. Journal of Molecular Biology

    JMB · 58 publications · 3.5K citations

    37

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 41 publications · 4.2K citations

    36

    h-index

  4. The EMBO Journal

    27 publications · 5.5K citations

    25

    h-index

  5. Biochemical and Biophysical Research Communications

    BBRC · 26 publications · 1K citations

    21

    h-index

1–5