Concepedia

Cd80 Interactions

CD80 Interactions is a molecular signaling construct that specifies the binding and functional engagement of the CD80 (B7-1) protein with its cognate receptors, CTLA-4 and CD28, on T cells, thereby governing the costimulatory signals requisite for adaptive immune activation and regulation.

146

Publications

10.7K

Citations

871

Authors

284

Institutions

Publications per year

2017–2026

19

Variants

B7-1 Interactions

Parents

Publications

146

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

P S Linsley, JoAnne L. Greene, William Brady et al. · Immunity · 1994 · 972 citations

, , +15

CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics

P. Anton van der Merwe, Dale L. Bodian, Susan Daenke et al. · The Journal of Experimental Medicine · 1997 · 547 citations

, , +17

PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways

Yunlong Zhao, Calvin K. Lee, Chia‐Hao Lin et al. · Immunity · 2019 · 391 citations · Full text

, , +17

Restriction of PD-1 function by <i>cis</i> -PD-L1/CD80 interactions is required for optimal T cell responses

Daisuke Sugiura, Takumi Maruhashi, Il‐mi Okazaki et al. · Science · 2019 · 377 citations

, , +17

B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance

Jang‐June Park, Ryusuke Omiya, Yumiko Matsumura et al. · Blood · 2010 · 322 citations · Full text

, , +14

1–5 of 146

Authors

871

  1. PS
    Peter S. Linsley

    Bristol-Myers Squibb (United States), United States

    5 publications · 1.1K citations

    5

    h-index

  2. SL
    Shoshana Levy

    Stanford University, United States

    4 publications · 280 citations

    4

    h-index

  3. RP
    Robert Peach

    Bristol-Myers Squibb (United States), United States

    4 publications · 1.5K citations

    4

    h-index

  4. AH
    Arlene H. Sharpe

    Harvard University, United States

    4 publications · 201 citations

    4

    h-index

  5. SA
    Sergio Abrignani

    Istituto Nazionale Genetica Molecolare, Italy

    3 publications · 367 citations

    3

    h-index

1–5 of 871

Institutions

284

  1. Harvard University

    Cambridge, United States

    7 h-index

    29 publications

    2.7K citations

  2. New York University

    New York, United States

    5 h-index

    17 publications

    1.6K citations

  3. Johns Hopkins University

    Baltimore, United States

    5 h-index

    23 publications

    2.4K citations

  4. Bristol-Myers Squibb (United States)

    New York, United States

    5 h-index

    33 publications

    9.5K citations

  5. Stanford University

    Stanford, United States

    5 h-index

    8 publications

    560 citations

  6. Heidelberg University

    Heidelberg, Germany

    4 h-index

    14 publications

    531 citations

  7. University of Oxford

    Oxford, United Kingdom

    4 h-index

    9 publications

    3.4K citations

  8. Johns Hopkins Medicine

    Baltimore, United States

    4 h-index

    15 publications

    2.3K citations

1–8 of 284

Venues

  1. The Journal of Immunology

    JI · 20 publications · 1.2K citations

    17

    h-index

  2. European Journal of Immunology

    EJI · 6 publications · 292 citations

    6

    h-index

  3. Immunity

    5 publications · 2K citations

    5

    h-index

  4. Blood

    5 publications · 517 citations

    5

    h-index

  5. International Immunology

    5 publications · 193 citations

    5

    h-index

1–5