Daisuke Sugiura

Restriction of PD-1 function by <i>cis</i> -PD-L1/CD80 interactions is required for optimal T cell responses

Daisuke Sugiura, Takumi Maruhashi, Il‐mi Okazaki et al. · Science · 2019 · 357 citations

PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice

Taku Okazaki, Il‐mi Okazaki, Jian Wang et al. · The Journal of Experimental Medicine · 2011 · 323 citations · Full text

LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII

Takumi Maruhashi, Il‐mi Okazaki, Daisuke Sugiura et al. · Nature Immunology · 2018 · 268 citations

Signal Transduction, Autoimmune Disease, Immunology +10

Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity

Takumi Maruhashi, Daisuke Sugiura, Il‐mi Okazaki et al. · Immunity · 2022 · 182 citations

Autoimmune Disease, T Cell Function, Peptide-mhc Class Ii +11

PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation

Reina Mizuno, Daisuke Sugiura, Kenji Shimizu et al. · Frontiers in Immunology · 2019 · 163 citations · Full text