Concepedia

Brca2 Deficiency

BRCA2 Deficiency is a genetic disorder characterized by impaired homologous recombination repair due to loss-of-function mutations in the BRCA2 gene, leading to genomic instability and increased susceptibility to malignancies, particularly breast and ovarian cancers.

297

Publications

27.9K

Citations

2.3K

Authors

700

Institutions

Publications per year

2017–2026

99

Parents

Publications

297

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

Helen Davies, Dominik Głodzik, Sandro Morganella et al. · Nature Medicine · 2017 · 1.1K citations · Full text

, , +14

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Shyam K. Sharan, Masami Morimatsu, Urs Albrecht et al. · Nature · 1997 · 1.1K citations · Full text

, , +16

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer

Jos Jonkers, Ralph Meuwissen, Hanneke van der Gulden et al. · Nature Genetics · 2001 · 1.1K citations

, , +16

Resistance to therapy caused by intragenic deletion in BRCA2

Stacey L. Edwards, Rachel Brough, Christopher J. Lord et al. · Nature · 2008 · 1K citations

, , +11

The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds

Sean V. Tavtigian, Jacques Simard, Johanna M. Rommens et al. · Nature Genetics · 1996 · 844 citations

, , +12

1–5 of 297

Authors

2.3K

  1. SK
    Shyam K. Sharan

    National Cancer Institute, United States

    10 publications · 2K citations

    10

    h-index

  2. AA
    Alan Ashworth

    Institute of Cancer Research, United Kingdom

    8 publications · 1.8K citations

    8

    h-index

  3. SB
    Sandra Burkett

    National Cancer Institute, United States

    7 publications · 408 citations

    7

    h-index

  4. MT
    Madalena Tarsounas

    CRUK/MRC Oxford Institute for Radiation Oncology, United Kingdom

    7 publications · 604 citations

    7

    h-index

  5. BK
    Betty K. Martin

    Cancer Genetics (United States), United States

    6 publications · 539 citations

    6

    h-index

1–5 of 2.3K

Institutions

700

  1. Cancer Genetics (United States)

    Rutherford, United States

    16 h-index

    89 publications

    7.7K citations

  2. National Cancer Institute

    Bethesda, United States

    16 h-index

    88 publications

    7.2K citations

  3. Center for Cancer Research

    Bethesda, United States

    14 h-index

    72 publications

    4K citations

  4. Institute of Cancer Research

    London, United Kingdom

    12 h-index

    94 publications

    22.9K citations

  5. Harvard University

    Cambridge, United States

    12 h-index

    39 publications

    6K citations

  6. Johns Hopkins University

    Baltimore, United States

    12 h-index

    64 publications

    4.3K citations

  7. Dana-Farber Cancer Institute

    Boston, United States

    11 h-index

    36 publications

    5.8K citations

  8. Memorial Sloan Kettering Cancer Center

    New York, United States

    11 h-index

    36 publications

    7.6K citations

1–8 of 700

Venues

  1. Nature Communications

    20 publications · 1.9K citations

    19

    h-index

  2. Oncogene

    14 publications · 682 citations

    14

    h-index

  3. Cancer Research

    12 publications · 1.5K citations

    12

    h-index

  4. PubMed

    Repository · 9 publications · 827 citations

    9

    h-index

  5. Nucleic Acids Research

    9 publications · 383 citations

    9

    h-index

1–5