Hanneke van der Gulden

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer

Jos Jonkers, Ralph Meuwissen, Hanneke van der Gulden et al. · Nature Genetics · 2001 · 1.1K citations

Medicine, Molecular Genetics, Oncology +16

Induction of medulloblastomas in<i>p53</i>-null mutant mice by somatic inactivation of<i>Rb</i>in the external granular layer cells of the cerebellum

Silvia Marino, Marc Vooijs, Hanneke van der Gulden et al. · Genes & Development · 2000 · 940 citations · Full text

Medicine, Developmental Biology, Oncology +17

Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis

Patrick W.B. Derksen, Xiaoling Liu, Francis N. Saridin et al. · Cancer Cell · 2006 · 594 citations · Full text

Medicine, Cancer Biology, Oncology +16

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human <i>BRCA1</i> -mutated basal-like breast cancer

Xiaoling Liu, Henne Holstege, Hanneke van der Gulden et al. · Proceedings of the National Academy of Sciences · 2007 · 479 citations · Full text

Medicine, Genetics, Oncology +15

The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin

Yifan Wang, Andrea J. Bernhardy, Cristina Cruz et al. · Cancer Research · 2016 · 271 citations · Full text

Medicine, Genetics, Oncology +16