Concepedia

Antigen Presentation Loss

Antigen Presentation Loss is a molecular mechanism in cancer immunology whereby tumor cells downregulate major histocompatibility complex class I molecules, thereby impairing the recognition and targeting of tumor antigens by cytotoxic T cells during metastatic progression.

146

Publications

15.3K

Citations

1.1K

Authors

379

Institutions

Publications per year

2017–2026

44

Parents

Publications

146

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

Donald M. O’Rourke, MacLean P. Nasrallah, Arati Desai et al. · Science Translational Medicine · 2017 · 1.8K citations · Full text

, , +17

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

Scott Gettinger, Jungmin Choi, Katherine Hastings et al. · Cancer Discovery · 2017 · 755 citations · Full text

, , +17

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells

Luc Van Kaer, Philip G. Ashton‐Rickardt, Hidde L. Ploegh et al. · Cell · 1992 · 727 citations

, , +17

Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia

Elena J. Orlando, Xia Han, Catherine Tribouley et al. · Nature Medicine · 2018 · 567 citations

, , +17

T-Cell Lymphoma Involving Subcutaneous Tissue

Christopher L. Gonzalez, L. Jeffrey Medeiros, Rita M. Braziel et al. · The American Journal of Surgical Pathology · 1991 · 479 citations

, , +17

1–5 of 146

Authors

1.1K

  1. SF
    Soldano Ferrone

    Massachusetts General Hospital, United States

    8 publications · 1.5K citations

    8

    h-index

  2. FG
    Federico Garrido

    Hospital Universitario Virgen de las Nieves, Spain

    6 publications · 458 citations

    6

    h-index

  3. FR
    Francisco Ruiz‐Cabello

    Hospital Universitario Virgen de las Nieves, Spain

    5 publications · 418 citations

    5

    h-index

  4. BS
    Barbara Seliger

    Martin Luther University Halle-Wittenberg, Germany

    5 publications · 587 citations

    5

    h-index

  5. AP
    Annette Paschen

    Essen University Hospital, Germany

    4 publications · 242 citations

    4

    h-index

1–5 of 1.1K

Institutions

379

  1. Heidelberg University

    Heidelberg, Germany

    9 h-index

    32 publications

    2K citations

  2. German Cancer Research Center

    Heidelberg, Germany

    7 h-index

    27 publications

    2.7K citations

  3. Hospital Universitario Virgen de las Nieves

    Granada, Spain

    7 h-index

    35 publications

    3K citations

  4. National Cancer Institute

    Bethesda, United States

    7 h-index

    29 publications

    5.7K citations

  5. National Institutes of Health

    Bethesda, United States

    6 h-index

    22 publications

    4K citations

  6. Massachusetts General Hospital

    Boston, United States

    6 h-index

    21 publications

    3.3K citations

  7. Harvard University

    Cambridge, United States

    6 h-index

    35 publications

    1.5K citations

  8. Inserm

    Paris, France

    5 h-index

    19 publications

    2.1K citations

1–8 of 379

Venues

  1. PubMed

    Repository · 11 publications · 803 citations

    11

    h-index

  2. The Journal of Immunology

    JI · 8 publications · 656 citations

    8

    h-index

  3. Nature Communications

    6 publications · 498 citations

    6

    h-index

  4. International Journal of Cancer

    6 publications · 339 citations

    6

    h-index

  5. British Journal of Cancer

    BJC · 5 publications · 469 citations

    5

    h-index

1–5