Publication | Open Access
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
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39
References
2017
Year
Cell TherapyAntigen LossImmunologyHigh-grade GliomasRecurrent GlioblastomaImmunotherapyGliomaNeuro-oncologyOncologyAutologous T CellsSpecific MutationInduces Adaptive ResistanceTolerance InductionCell BiologyCancer ImmunosurveillanceImmune Checkpoint InhibitorGlioblastoma PatientsMedicineTherapy Resistance
A trial of autologous T cells redirected to a specific mutation in glioblastoma patients illustrates mechanisms of resistance.
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