Concepedia

Antibody Lead Optimization

Antibody Lead Optimization is a systematic research phase in therapeutic antibody development that refines initial candidate antibodies through iterative structural and functional modifications to enhance their binding affinity, specificity, stability, and developability while minimizing immunogenicity.

71

Publications

3.5K

Citations

719

Authors

175

Institutions

Publications per year

2017–2026

37

Parents

Publications

71

Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured fab in complex with antigen 1 1Edited by I. A. Wilson

Yvonne Chen, Christian Wiesmann, Germaine Fuh et al. · Journal of Molecular Biology · 1999 · 447 citations

, , +14

Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design

Ron Diskin, Johannes F. Scheid, Paola Marcovecchio et al. · Science · 2011 · 377 citations

, , +13

A strategy for risk mitigation of antibodies with fast clearance

Isidro Hötzel, Frank‐Peter Theil, L. Bernstein et al. · mAbs · 2012 · 247 citations · Full text

, , +17

Structure-Based Design of Supercharged, Highly Thermoresistant Antibodies

Aleksandr E. Miklos, Christien Kluwe, Bryan S. Der et al. · Chemistry & Biology · 2012 · 142 citations

, , +14

Rapid and accurate in silico solubility screening of a monoclonal antibody library

Pietro Sormanni, Leanne Amery, Sofia Ekizoglou et al. · Scientific Reports · 2017 · 141 citations · Full text

, , +17

1–5 of 71

Authors

719

  1. IH
    Isidro Hötzel

    Washington State University, United States

    4 publications · 310 citations

    4

    h-index

  2. PS
    Pietro Sormanni

    University of Cambridge, United Kingdom

    3 publications · 204 citations

    3

    h-index

  3. JE
    James E. Crowe

    Vanderbilt University Medical Center, United States

    3 publications · 83 citations

    3

    h-index

  4. MV
    Michele Vendruscolo

    University of Cambridge, United Kingdom

    3 publications · 204 citations

    3

    h-index

  5. JM
    Jens Meiler

    Vanderbilt University, United States

    3 publications · 83 citations

    3

    h-index

1–5 of 719

Institutions

175

  1. University of Cambridge

    Cambridge, United Kingdom

    4 h-index

    14 publications

    746 citations

  2. Johns Hopkins University

    Baltimore, United States

    3 h-index

    9 publications

    775 citations

  3. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    22 publications

    480 citations

  4. Vanderbilt University

    Nashville, United States

    3 h-index

    17 publications

    490 citations

  5. University of Milan

    Milan, Italy

    2 h-index

    5 publications

    178 citations

  6. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    2 h-index

    13 publications

    256 citations

  7. Aimmune Therapeutics (United Kingdom)

    London, United Kingdom

    2 h-index

    13 publications

    648 citations

  8. National Research Council Canada

    Ottawa, Canada

    2 h-index

    23 publications

    804 citations

1–8 of 175

Venues

  1. mAbs

    13 publications · 704 citations

    12

    h-index

  2. Protein Engineering Design and Selection

    PEDS · 6 publications · 175 citations

    6

    h-index

  3. PLoS ONE

    4 publications · 133 citations

    4

    h-index

  4. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 4 publications · 127 citations

    4

    h-index

  5. Journal of Medicinal Chemistry

    4 publications · 138 citations

    4

    h-index

1–5