Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

Johannes F. Scheid, Hugo Mouquet, Beatrix Ueberheide, +19

Science

ImmunologyMolecular BiologyAntigen ProcessingViral Structural ProteinImmunotherapy +16

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

Tongqing Zhou, Ivelin S. Georgiev, Xueling Wu, +15

Science

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

Johannes F. Scheid, Hugo Mouquet, Niklas Feldhahn, +19

Nature

Hiv-infected IndividualsHuman RetrovirusHumoral ResponseImmunologyAntiviral Response +7

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

Marina Caskey, Florian Klein, Julio C. C. Lorenzi, +22

Nature

Human RetrovirusAntibody 3Bnc117ImmunologyAntiviral TherapyAntiviral Response +5

Complex-type <i>N</i> -glycan recognition by potent broadly neutralizing HIV antibodies

Hugo Mouquet, Louise Scharf, Zelda Euler, +11

Proceedings of the National Academy of Sciences

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

Florian Klein, Ron Diskin, Johannes F. Scheid, +13

Cell

Primary ImmunodeficiencySomatic VariantSomatic MutationsHuman RetrovirusImmunology +6

A robust pipeline for rapid production of versatile nanobody repertoires

Peter C. Fridy, Yinyin Li, Sarah Keegan, +8

Nature Methods

NanoroboticsEngineeringNanomaterialsNanotechnologyNanobiotechnology +9

HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

Florian Klein, Ariel Halper-Stromberg, Joshua A. Horwitz, +20

Nature

Human RetrovirusImmunologyAntiviral TherapyAntiviral ResponseAntibody Engineering +5

HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption

Johannes F. Scheid, Joshua A. Horwitz, Yotam Bar‐On, +30

Nature

Viral PersistenceHuman RetrovirusImmunologyAntiviral ResponseAntiviral Therapy +8

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

Hugo Mouquet, Johannes F. Scheid, Michelle Krogsgaard, +16

Nature

MedicineHuman RetrovirusImmunologyAntiviral TherapyAntiviral Response +5