Concepedia

Aggregation Mitigation

Aggregation Mitigation is a protein engineering strategy that reduces the propensity of therapeutic proteins to form higher-order, potentially immunogenic aggregates by stabilizing their structural conformation or minimizing intermolecular interactions under physiological and storage conditions.

96

Publications

5.6K

Citations

475

Authors

193

Institutions

Publications per year

2017–2026

38

Parents

Publications

96

Supercharging Proteins Can Impart Unusual Resilience

Michael S. Lawrence, Kevin J. Phillips, David R. Liu · Journal of the American Chemical Society · 2007 · 547 citations · Full text

, , +17

Controlled food protein aggregation for new functionality

Taco Nicolaï, Dominique Durand · Current Opinion in Colloid & Interface Science · 2013 · 337 citations

, , +12

Prediction of Aggregation Prone Regions of Therapeutic Proteins

Naresh Chennamsetty, Vladimir Voynov, Veysel Kayser et al. · The Journal of Physical Chemistry B · 2010 · 204 citations

, , +17

Reversible protein aggregation is a protective mechanism to ensure cell cycle restart after stress

Shady Saad, Gea Cereghetti, Yuehan Feng et al. · Nature Cell Biology · 2017 · 202 citations

, , +16

Review of the current state of protein aggregation inhibition from a materials chemistry perspective: special focus on polymeric materials

Robin Rajan, Sana Ahmed, Neha Sharma et al. · Materials Advances · 2021 · 186 citations · Full text

, , +17

1–5 of 96

Authors

475

  1. TW
    Theodore W. Randolph

    University of Colorado Boulder, United States

    4 publications · 251 citations

    4

    h-index

  2. KK
    Kazushi Kinbara

    The University of Tokyo, Japan

    3 publications · 107 citations

    3

    h-index

  3. ZJ
    Zheng Jian Li

    Bristol-Myers Squibb (United States), United States

    3 publications · 127 citations

    3

    h-index

  4. KA
    Kota Adachi

    Tohoku University, Japan

    3 publications · 107 citations

    3

    h-index

  5. JF
    John F. Carpenter

    University of Colorado Boulder, United States

    3 publications · 224 citations

    3

    h-index

1–5 of 475

Institutions

193

  1. Tohoku University

    Sendai, Japan

    4 h-index

    22 publications

    786 citations

  2. University of Cambridge

    Cambridge, United Kingdom

    4 h-index

    10 publications

    1K citations

  3. Bristol-Myers Squibb (United States)

    New York, United States

    4 h-index

    17 publications

    1.2K citations

  4. University of Colorado Boulder

    Boulder, United States

    4 h-index

    17 publications

    1.1K citations

  5. Amgen (United States)

    Thousand Oaks, United States

    3 h-index

    17 publications

    1.8K citations

  6. Ludwig-Maximilians-Universität München

    Munich, Germany

    3 h-index

    15 publications

    537 citations

  7. Bristol-Myers Squibb (Germany)

    Munich, Germany

    3 h-index

    14 publications

    657 citations

  8. Massachusetts Institute of Technology

    Cambridge, United States

    3 h-index

    11 publications

    1.3K citations

1–8 of 193

Venues

  1. Journal of Pharmaceutical Sciences

    8 publications · 232 citations

    8

    h-index

  2. 5

    h-index

  3. RSC Advances

    5 publications · 155 citations

    5

    h-index

  4. Biotechnology Progress

    4 publications · 146 citations

    4

    h-index

  5. Biotechnology and Bioengineering

    4 publications · 130 citations

    4

    h-index

1–5