Concepedia

Active Site Plasticity

Active Site Plasticity is the conformational adaptability of an enzyme's active site that enables selective substrate recognition and catalytic efficiency through structural changes in response to substrate binding.

38

Publications

1.3K

Citations

209

Authors

96

Institutions

Publications per year

2017–2026

11

Parents

Publications

38

Novel enzyme activities and functional plasticity revealed by recombining highly homologous enzymes

SunAi Raillard, Anke Krebber, Yonghong Chen et al. · Chemistry & Biology · 2001 · 113 citations · Full text

, , +16

Active Site Plasticity in <scp>d</scp>-Amino Acid Oxidase:  A Crystallographic Analysis<sup>,</sup>

Flavia Todone, Maria A. Vanoni, Andrea Mozzarelli et al. · Biochemistry · 1997 · 87 citations

, , +17

Dynamic Conformational States Dictate Selectivity toward the Native Substrate in a Substrate-Permissive Acyltransferase

Olesya Levsh, Ying‐Chih Chiang, Chun Fai Tung et al. · Biochemistry · 2016 · 82 citations · Full text

, , +17

Active Site Plasticity within the Glycoside Hydrolase NagZ Underlies a Dynamic Mechanism of Substrate Distortion

J.P. Bacik, Garrett E. Whitworth, Keith A. Stubbs et al. · Chemistry & Biology · 2012 · 82 citations · Full text

, , +14

The Molecular Basis for the Broad Substrate Specificity of Human Sulfotransferase 1A1

Ilana Berger Fridman, Chen Guttman, Dotan Amar et al. · PLoS ONE · 2011 · 66 citations · Full text

, , +17

1–5 of 38

Authors

209

  1. VN
    Valakunja Nagaraja

    Indian Institute of Science Bangalore, India

    2 publications · 28 citations

    2

    h-index

  2. DH
    Donald Hilvert

    ETH Zurich, Switzerland

    2 publications · 40 citations

    2

    h-index

  3. AM
    Andrea Mozzarelli

    University of Parma, Italy

    2 publications · 102 citations

    2

    h-index

  4. KV
    Kommireddy Vasu

    Jawaharlal Nehru Centre for Advanced Scientific Research, India

    2 publications · 28 citations

    2

    h-index

  5. YC
    Yonghong Chen

    Huainan Normal University, China

    1 publications · 113 citations

    1

    h-index

1–5 of 209

Institutions

96

  1. Scripps Research Institute

    San Diego, United States

    3 h-index

    10 publications

    499 citations

  2. ETH Zurich

    Zurich, Switzerland

    2 h-index

    7 publications

    164 citations

  3. Lomonosov Moscow State University

    Moscow, Russia

    2 h-index

    8 publications

    152 citations

  4. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    5 publications

    266 citations

  5. University of Oxford

    Oxford, United Kingdom

    2 h-index

    6 publications

    262 citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    3 publications

    110 citations

  7. Jawaharlal Nehru Centre for Advanced Scientific Research

    Bengaluru, India

    2 h-index

    9 publications

    147 citations

  8. University of Minnesota

    Minneapolis, United States

    2 h-index

    7 publications

    296 citations

1–8 of 96

Venues

  1. Biochemistry

    5 publications · 293 citations

    5

    h-index

  2. Journal of Biological Chemistry

    JBC · 3 publications · 82 citations

    3

    h-index

  3. Antimicrobial Agents and Chemotherapy

    AAC · 2 publications · 49 citations

    2

    h-index

  4. Chemistry & Biology

    2 publications · 195 citations

    2

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 86 citations

    2

    h-index

1–5