Donald Hilvert

De Novo Computational Design of Retro-Aldol Enzymes

Lin Jiang, Eric A. Althoff, Fernando R. Clemente et al. · Science · 2008 · 1.2K citations

Biosynthesis, Aldo-keto Reductase, Biochemistry +14

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

Justin B. Siegel, Alexandre Zanghellini, Helena M. Lovick et al. · Science · 2010 · 917 citations

Bioorganic Chemistry, Engineering, Biochemistry +15

Precision is essential for efficient catalysis in an evolved Kemp eliminase

Rebecca Blomberg, Hajo Kries, Daniel M. Pinkas et al. · Nature · 2013 · 341 citations

Engineering, Biochemistry, Bioenergetics +12

An evolution-based model for designing chorismate mutase enzymes

William P. Russ, Matteo Figliuzzi, Christian Stocker et al. · Science · 2020 · 340 citations

Engineering, Quantitative Complementation Assay, Molecular Biology +19

Iterative approach to computational enzyme design

Heidi K. Privett, Gert Kiss, Toni M. Lee et al. · Proceedings of the National Academy of Sciences · 2012 · 334 citations · Full text

Engineering, Protein Assembly, Molecular Biology +16